Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor [PDF]
, 2013 Context: The onset of labor appears to involve the activation of myometrial inflammatory pathways, and transcription factors such as nuclear factor-κB (NF-κB) control expression of the contraction-associated proteins required to induce a procontractile ...
Bari, Muhammad F. +4 more
core +1 more source
Медицинская иммунология, 2014 . Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova +5 more
doaj +1 more source
NKT Cells Join the Two Step for Inflammasome-Independent IL-1β Release
Cell Reports, 2020 The cytokine interleukin-1β (IL-1β) is critical for antimicrobial defenses; the inflammasome pathway typically controls IL-1β release, but pathogens often evade this pathway. In this issue, Donado et al. (2020) describe an alternative, two-cell model, to
Jelena S. Bezbradica, Sebastian Joyce
doaj +1 more source
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.
Journal of Clinical Investigation, 2020 Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1β.
K. Bulek +19 more
semanticscholar +1 more source
Peran Magnesium Sulfat dalam Menurunkan Kadar TNF-α dan IL-1β pada Bayi Prematur
Jurnal Kedokteran Brawijaya, 2017 Prematuritas menyebabkan mortalitas dan morbiditas neonatus yaitu cerebral palsy (CP), gangguan kognitif dan gangguan tingkah laku. Sitokin proinflamasi TNF-α dan IL-1β diduga secara signifikan meningkat pada bayi prematur. Magnesium sulfat (MgSO4) diduga dapat sebagai neuroprotektor terhadap otak janin, melindungi jaringan terhadap aktivitas radikal
Sri Sulistyowati +3 more
openaire +2 more sources
Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms
Frontiers in Immunology, 2018 Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review,
Yaoyao Xia +11 more
doaj +1 more source
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β [PDF]
, 2015 The Notch1 and Notch4 signaling pathways regulate endothelial cell homeostasis. Inflammatory cytokines induce the expression of endothelial adhesion molecules, including VCAM1, partly by downregulating Notch4 signaling.
Adesso, Laura +15 more
core +3 more sources
Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils
Frontiers in Immunology, 2018 Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which a canonical mechanism of secretion remains to be established.
Leonardo Iula +13 more
doaj +1 more source
Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma [PDF]
, 2012 Copyright @ 2012 Spandidos Publications Ltd. This article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.Choriocarcinoma is a highly malignant epithelial tumour that is most often ...
Karteris, E +4 more
core +1 more source
Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
eLife, 2015 Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang +4 more
doaj +1 more source