Results 31 to 40 of about 2,339,252 (343)

Comparison of TNF-α and IL-1β Concentrations in Gingival Crevicular Fluid During Early Alignment Stage of Orthodontic Treatment in Adults and Adolescents [PDF]

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2020
Objective:  To compare the levels of TNF- α  and IL-1 β  in the gingival crevicular fluid (GCF) during early leveling stage of orthodontic treatment.  Material and Methods: This study was carried out on 20 orthodontic patients, including 10 teenagers and 10 adults.
Marzieh Karimi Afshar, Fereshteh Safarian, Molook Torabi, Alireza Farsinejad, Iman Mohammadzadeh   +4 more
openaire   +3 more sources

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Journal of Neuroinflammation, 2019
Background Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the related mechanisms remain vague.
Yi Sun, Jiangjun Ma, Dongfang Li, Pinggan Li, Xiaolin Zhou, Yu Li, Zhanwen He, Lijun Qin, Liyang Liang, Xiangyang Luo   +9 more
doaj   +1 more source

Additional file 1: of HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

, 2018
Table S1. Primers list used for quantitative real-time PCR analysis of different genes. Figure S1. Confirmation of HSP60 knockdown by vivo morpholino in mice brain. Figure S2. The overexpression of HSP60 was confirmed by Western blot. Figure S3. JEV induces inflammation in N9 murine microglial cells at MOI 2. (DOCX 1066 kb)
Swaroop, Shalini, Mahadevan, Anita, Susarla Shankar, Adlakha, Yogita, Anirban Basu   +4 more
openaire   +1 more source

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages [PDF]

Scientific Reports, 2019
AbstractInflammation and metabolism are intricately linked during inflammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) inflammasome, an innate immune sensor, is critical.
Orla M. Finucane, Jamie Sugrue, Ana Rubio-Araiz, Marie-Victoire Guillot-Sestier, Marina A. Lynch   +4 more
openaire   +5 more sources

Peran Magnesium Sulfat dalam Menurunkan Kadar TNF-α dan IL-1β pada Bayi Prematur

Jurnal Kedokteran Brawijaya, 2017
Prematuritas menyebabkan mortalitas dan morbiditas neonatus yaitu cerebral palsy (CP), gangguan kognitif dan gangguan tingkah laku. Sitokin proinflamasi TNF-α dan IL-1β diduga secara signifikan meningkat pada bayi prematur. Magnesium sulfat (MgSO4) diduga dapat sebagai neuroprotektor terhadap otak janin, melindungi jaringan terhadap aktivitas radikal
Ferri Waluyo Wiwoho Pujojati, Sri Sulistyowati, Soetrisno, Supriyadi Hari Respati   +3 more
openaire   +3 more sources

A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells [PDF]

Journal of Cellular and Molecular Medicine, 2009
AbstractThe histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on β‐cells, but it is unable to protect β‐cells from death due to its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective effects against IL‐1β‐induced damage to isolated β‐cells.
Anjaneyulu Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Patrick M. Woster, Thulani Senanayake, Laura Susick   +5 more
openaire   +3 more sources

Immunomodulatory Effect of Nigella sativa Extract through the Improvement of IL-1β Level in Balb-c Mice Infected by Methicillin-resistant Staphylococcus aureus

Jurnal Kedokteran Brawijaya, 2020
Nigella sativa (NS) has been used for many years as an anti-bacterial herbal treatment, such as Methicillin-resistant Staphylococcus aureus, but the mechanism in bacterial elimination is still unknown. IL-1β is a proinflammatory cytokine that helps the immune system eliminate microbes when it enters the body. The purpose of this study was to prove the
Galuh Yulieta Nitihapsari, Octavia Permata S, Miko Ferine   +2 more
openaire   +3 more sources

A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages [PDF]

Frontiers in Microbiology, 2015
Vibrio fluvialis causes human diarrhea, but the pathogenesis is not well-studied. We hypothesized that V. fluvialis-secreted hemolysin (VFH) may induce IL-1β secretion through the activation of the NLRP3 inflammasome and contribute to the pathogenicity of V. fluvialis.
Biao Kan, Zhihong Ren, Zhihao Wang, Liqiong Song, Hui Sun, Weili Liang, Guangxun Meng, Shujing Wang, Meng Zhao, Yuanming Huang   +9 more
openaire   +3 more sources

The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice

European Journal of Immunology, 2018
The pro‐inflammatory cytokine IL‐1β is well known for its role in host defense and the initiation of potent inflammatory responses. It is processed from its inactive pro‐form by the inflammatory caspase‐1 into its mature bioactive form, which is then ...
Rosalie Heilig, Mathias S Dick, Lorenzo Sborgi, E. Meunier, S. Hiller, P. Brož   +5 more
semanticscholar   +1 more source

Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair

Science Advances, 2020
Platelet microparticles are used to deliver IL-1β antibodies to myocardial infarction for cardiac detoxing and repair. An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates further heart injury and promotes adverse
Zhenhua Li, Shiqi Hu, Ke Huang, Teng Su, Jhon Cores, K. Cheng   +5 more
semanticscholar   +1 more source