Results 51 to 60 of about 2,610,317 (379)

Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent [PDF]

Frontiers in Immunology, 2019
Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to resolve this inflammation, resulting in endometritis, which compromises fertility. Earlier work has identified upregulated expression of the potent inflammatory cytokine IL-1β early post-partum, in ...
Paul Kelly, Kieran G. Meade, Cliona O’Farrelly   +2 more
openalex   +7 more sources

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance There is a growing understanding that inflammation impairs synaptic plasticity and cognition and that the aged brain has an elevated sensitivity to cognitive impairment by the proinflammatory cytokine interleukin 1β (IL-1β). IL-1β activates different pathways via AcP (proinflammatory) or AcPb (prosurvival) IL-1 receptor subunits.
Prieto, GA, Snigdha, S, Baglietto-Vargas, D, Smith, ED, Berchtold, NC, Tong, L, Ajami, D, Laferla, FM, Rebek, J, Cotman, CW   +9 more
openaire   +6 more sources

Ragweed pollen extract intensifies lipopolysaccharide-induced priming of NLRP3 inflammasome in human macrophages [PDF]

, 2012
Ragweed pollen extract (RWE) possesses intrinsic NADPH oxidase activity that induces oxidative stress by initiating the production of intracellular reactive oxygen species (ROS).
Benkő, Szilvia, Budai, Marietta, Bácsi, Attila, Milesz, Sándor, Tőzsér, József, Varga, Alíz   +5 more
core   +1 more source

CARD9+ Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

Nature Immunology, 2019
The C-type lectin receptor–Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human deficiency in CARD9 causes susceptibility to fungus-specific, CNS-targeted infection. CARD9
Rebecca A. Drummond, M. Swamydas, Vasileios Oikonomou, B. Zhai, I. Dambuza, B. Schaefer, Andrea C. Bohrer, K. Mayer-Barber, S. Lira, Y. Iwakura, S. Filler, Gordon D. Brown, B. Hube, J. Naglik, T. Hohl, M. Lionakis   +15 more
semanticscholar   +1 more source

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions [PDF]

Frontiers in Immunology, 2015
Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted.
Monique eStoffels, Monique eStoffels, Ruben eZaal, Ruben eZaal, Nina eKok, Nina eKok, Jos W.M. van der Meer, Jos W.M. van der Meer, Charles A. Dinarello, Charles A. Dinarello, Anna eSimon, Anna eSimon   +11 more
openaire   +5 more sources

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro [PDF]

, 2017
Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis.
Ahmad, Narmeen, El-Refaee, Mohammed, Jackson, Andrew M., Martin, Stewart G., Safuan, Sabreena, Storr, Sarah J.   +5 more
core   +2 more sources

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

Journal of Neuroinflammation, 2019
Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate the inflammatory process of microglia in several ...
Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yixin Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zhou   +8 more
semanticscholar   +1 more source

Targeting IL-1β in the Treatment of Atherosclerosis

Frontiers in Immunology, 2020
The role of inflammation in atherosclerosis has been recognized several decades ago and existing treatments provide benefits in part through non-specific anti-inflammatory actions.
Wuqian Mai, Yuhua Liao
semanticscholar   +1 more source

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Cell Reports, 2018
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis.
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder   +13 more
doaj   +1 more source

Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]

, 2017
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario, Braghetta, Paola, Bressan, Giorgio M., Carnevale, Daniela, Carnevale, Lorenzo, Carnevale, Raimondo, Casaburo, Manuel, Cifelli, Giuseppe, DA ROS, Francesco, Fardella, Stefania, Iacobucci, Roberta, Lembo, Giuseppe, Perrotta, Marialuisa, Vinciguerra, Iolanda   +13 more
core   +1 more source