Results 71 to 80 of about 2,610,317 (379)

Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair

Science Advances, 2020
Platelet microparticles are used to deliver IL-1β antibodies to myocardial infarction for cardiac detoxing and repair. An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates further heart injury and promotes adverse
Zhenhua Li, Shiqi Hu, Ke Huang, Teng Su, Jhon Cores, K. Cheng   +5 more
semanticscholar   +1 more source

Alteration of dopamine, homovanillic acid (HVA) with interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cerebral palsy

Biodiversitas Journal of Biological Diversity, 1970
Now, diagnosis of cerebral palsy base only on clinical finding without involve the alteration of the neurochemistry cause by cerebral hypoxic, although cerebral palsy is a syndrome cause by cerebral hypoxic; so, the accuracy diagnosis of this disease is very low.
openaire   +2 more sources

The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy [PDF]

Frontiers in Cellular Neuroscience, 2014
Epilepsy is a neurological disorder characterized by a hyperexcitable brain tissue and unpredictable seizures, i.e., aberrant firing discharges in large neuronal populations. It is well established that proinflammatory cytokines, in addition to their canonical involvement in the immune response, have a crucial role in the mechanism of seizure ...
Chiavegato, Angela, Zurolo, Emanuele, Losi, Gabriele, Aronica, Eleonora, Carmignoto, Giorgio   +4 more
openaire   +4 more sources

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility [PDF]

, 2018
Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear.
Anthony, D C, Consentino Kronka Sosthenes, M, Couch, Y, Evans, M C, Roodselaar, J, Stolp, H B, Sá-Pereira, I   +6 more
core   +2 more sources

Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways

International Journal of Molecular Sciences, 2019
Quercetin, a bioflavonoid derived from vegetables and fruits, exerts anti-inflammatory effects in various diseases. Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion ...
Shu-Chen Cheng, Wen-Chung Huang, Jong-Hwei S. Pang, Yi-Hong Wu, Ching-Yi Cheng   +4 more
semanticscholar   +1 more source

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages [PDF]

Journal of Biological Chemistry, 2015
Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it specifically inhibited pro-IL-1β production, having no effect on TNF-α.
Beth Kelly, Gillian M. Tannahill, Michael P. Murphy, Luke A. J. O'Neill   +3 more
openaire   +4 more sources

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes[S]

Journal of Lipid Research, 2014
This study examined the role of interleukin (IL)-1 receptor-associated kinase (IRAK) and protein kinase C (PKC) in oxidized LDL (Ox-LDL)-induced monocyte IL-1β production.
Rajiv Lochan Tiwari, Vishal Singh, Ankita Singh, Minakshi Rana, Anupam Verma, Nikhil Kothari, Monica Kohli, Jaishri Bogra, Madhu Dikshit, Manoj Kumar Barthwal   +9 more
doaj   +1 more source

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression

Journal of Neuroinflammation, 2019
Chronic pain is a major clinical problem with limited treatment options. Previous studies have demonstrated that activation of adenosine monophosphate-activated protein kinase (AMPK) can attenuate neuropathic pain.
Hongchun Xiang, Lixue Lin, Xuefei Hu, He Zhu, Hongping Li, Ru-Yue Zhang, Liang Hu, Wen-tao Liu, Yi-Lin Zhao, Yang Shu, H. Pan, Man Li   +11 more
semanticscholar   +1 more source