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Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19. [PDF]

open access: yesNat Neurosci
Fekete R   +23 more
europepmc   +1 more source

IL-1 Family Members in Bone Sarcomas. [PDF]

open access: yesCells
Landuzzi L   +5 more
europepmc   +1 more source
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IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

The Journal of Immunology, 1990
Abstract IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or ...
Schindler, R, Ghezzi, P, Dinarello, C A
openaire   +3 more sources

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19: anti-inflammatory strategies.

Journal of Biological Regulators and Homeostatic Agents, 2020
COVID-19 (coronavirus disease-19) involves humans as well as animals and may cause serious damage to the respiratory tract including the lung. This pathogenic virus has been identified in swabs performed on the throat and nose of patients who suffer from
P. Conti   +6 more
semanticscholar   +1 more source

IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.

The Journal of Immunology, 1988
Abstract IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory diseases. We have recently shown that IL-1 induces its own gene expression and, in the present studies, we have examined the effect of IFN-gamma on IL-1-induced IL-1 production. Whereas IFN-gamma increases the total amount of IL-1 (
Ghezzi, P, Dinarello, C A
openaire   +3 more sources

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