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IL-1 as a target in inflammation
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015Inflammation is a protective response to eliminate cytotoxic agents and pathogens. Various factors are thought to be involved in the pathological changes in tissues caused by inflammation. Interleukin 1, an inflammatory cytokine, is thought to have diverse physiological functions and to play an important role in inflammatory disease. In this review, we
Yuki, Ito +5 more
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Expert Opinion on Therapeutic Targets, 2012
Depression is associated with inflammation, Th1 and Th17 responses, oxidative and nitrosative stress (O&NS), autoimmune responses against neoantigenic determinants, and neuroprogression (i.e., neurodegeneration, impaired plasticity and reduced neurogenesis).
Michael, Maes, Cai, Song, Raz, Yirmiya
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Depression is associated with inflammation, Th1 and Th17 responses, oxidative and nitrosative stress (O&NS), autoimmune responses against neoantigenic determinants, and neuroprogression (i.e., neurodegeneration, impaired plasticity and reduced neurogenesis).
Michael, Maes, Cai, Song, Raz, Yirmiya
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IL-1 induces rapid phosphorylation of the IL-1 receptor.
The Journal of Immunology, 1989Abstract The IL-1R on murine T cells is a Mr = 80,000 plasma membrane glycoprotein. cDNA cloning and transfection experiments have shown that this is an integral membrane protein, which binds both IL-1 alpha and IL-1 beta and transduces the IL-1 signal.
B, Gallis +6 more
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Anti-IL-1 Activity of Peptide Fragments of IL-1 Family Proteins
Peptides, 1998A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.
I Z, Siemion, A, Kluczyk, Z, Wieczorek
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Immunity
Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social ...
Jinsu Lee, Michael A. Wheeler
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Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social ...
Jinsu Lee, Michael A. Wheeler
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2014
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2013
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2015
We have investigated the effect of systemic therapy of obesity on regulation of cytokine IL-1?? synthesis in psoriasis patients produced by healthy donors??? keratinocytes through mononuclear leukocytes (leptin-induced) in vitro. It has been shown that the treatment course with use of acarbose results in a statistically significant reduction or ...
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We have investigated the effect of systemic therapy of obesity on regulation of cytokine IL-1?? synthesis in psoriasis patients produced by healthy donors??? keratinocytes through mononuclear leukocytes (leptin-induced) in vitro. It has been shown that the treatment course with use of acarbose results in a statistically significant reduction or ...
openaire +1 more source