Results 241 to 250 of about 2,185,989 (294)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

D24. Financial Toxicity Associated With Cleft Palate Repair: A Survey of Family Financial Well-being

Plastic and Reconstructive Surgery, Global Open
Sophia Allison, BA, Hannah Soltani, BA, Emily Chwa, BS, Rachel Donaldson, BS, Arun Gosain, MD   +4 more
doaj   +1 more source

Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells. [PDF]

Int J Mol Sci
Mazzone A, Della Rocca Y, Flamminii F, Guarnieri S, Bello DG, Nanci A, Trubiani O, Diomede F, Pizzicannella J.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer. [PDF]

Sci Rep
Toney NJ, Opdenaker LM, Frerichs L, Modarai SR, Ma A, Archinal H, Ajayi GO, Sims-Mourtada J.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma. [PDF]

Mol Ther Oncol
Yun K, Sakemura RL, Can I, Gutierrez Ruiz O, Ogbodo EJ, Zhang S, Saleh A, Huynh TN, Manriquez Roman C, Sirpilla OL, Stewart CM, Girsch JH, Feigin JM, Mai L, Xia H, Kimball B, Kankeu Fonkoua LA, Hefazi M, Ruff MW, Rohakhtar FR, Simon V, Siegler EL, Mattie M, Nguyen-Mau SM, Filosto S, Kenderian SS.   +25 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Taming the flame: WAS and IL-1 blockade.

Blood
Pai SY.
europepmc   +1 more source

Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways. [PDF]

Brain Sci
Oliveira ACDR, Figueiredo CS, Raony Í, Von-Held-Ventura JS, Granja MG, Mázala-de-Oliveira T, Pedrosa-Soares VH, Dos Santos AA, Giestal-de-Araujo E.   +8 more
europepmc   +1 more source