Results 221 to 230 of about 1,896,687 (246)

Targeting IL-1 in depression

Expert Opinion on Therapeutic Targets, 2012
Depression is associated with inflammation, Th1 and Th17 responses, oxidative and nitrosative stress (O&NS), autoimmune responses against neoantigenic determinants, and neuroprogression (i.e., neurodegeneration, impaired plasticity and reduced neurogenesis).
Michael, Maes, Cai, Song, Raz, Yirmiya
openaire   +2 more sources

Anti-IL-1 Activity of Peptide Fragments of IL-1 Family Proteins

Peptides, 1998
A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 competition depends on the presence of such motifs in IL-1 proteins.
I Z, Siemion, A, Kluczyk, Z, Wieczorek
openaire   +2 more sources

IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor

The Journal of Immunology, 1998
Abstract The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1β and the IL-1 type-IR (IL-1RI), but an essential requirement for IL-1R AcP in IL-1 signaling in vitro has not been established and its role in vivo has not been examined.
E B, Cullinan, L, Kwee, P, Nunes, D J, Shuster, G, Ju, K W, McIntyre, R A, Chizzonite, M A, Labow   +7 more
openaire   +2 more sources

Species-specific binding of IL-1, but not the IL-1 receptor antagonist, by fibroblasts

Cytokine, 1994
Our laboratory previously reported that bovine thymocytes and fibroblasts proliferated only in response to bovine IL-1, whereas proliferation of murine thymocytes was augmented equally well by murine, human, and bovine IL-1. In this study, we used direct and competitive receptor binding assays to determine whether differential binding of homologous ...
J A, Lederer, C J, Czuprynski
openaire   +2 more sources

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways

NeuroReport, 2005
The cytokine interleukin (IL)-1 plays important roles in peripheral and central inflammation via the actions of two ligands IL-1 alpha and IL-1beta that bind to the IL-1 type I receptor (IL-1RI) and trigger identical responses. However, some recent evidence suggests that IL-1alpha and IL-1beta may have differential actions in the CNS.
Andre, Ralph, Pinteaux, Emmanuel; id_orcid 0000-0002-9986-4401, Kimber, Ian, Rothwell, Nancy J.   +3 more
openaire   +3 more sources

Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection.

The Journal of Immunology, 1994
Abstract IL-1 pretreatment prolongs survival in lethal infection in normal and in neutropenic mice. We investigated whether this protection occurs by interference with deleterious cytokine effects. The effect of IL-1 pretreatment on concentrations of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha circulating in vivo and the ex vivo ...
Vogels, M.T.E., Mensink, E.J.B.M., Ye, K., Boerman, O.C., Verschueren, C.M.M., Dinarello, C.A., Meer, J.W.M. van der   +6 more
openaire   +3 more sources

IL-1 Receptor Family

2017
IL-1 receptor ...
openaire   +3 more sources

???????????????? ???????????? ???????????????????????????????????? ???????????????? IL-1?? ?? ???????????????????????????? ?????????????? ?????? ???????????????? ?????????????????? ???????? ?????????????? ???????????????????? ???????? ?? ??????, ???????????????????? ???????????????????? ????????????

2014
?? ???????????? ???? ?????????????????? ?????????????????????????? ?????????????????????????? ???????????? (????????), ?????? ?????????????????? ?????????????????????? (??????) ????????????, ?????????????? ?????????? ???????????? ???????? ?????????????????? ???? ?????????????????????? (?? ???????????????????????? ????????????????????) ???????????? ?????
openaire   +1 more source

??????????????-???????????????????????????? ???????????? ???????????????????????????????????? ???????????????? IL-1?? ?????????????????????????????? ?????????????????????? ?????? ?????????????????????? ?????????????????? ?? ?????????????????????? ???????????????? ?????????????????????????????? ?? ?????????????? ?? ???????????????????? ???????????? ??????????????????????????

2013
?? ???????????? ???? ?????? ?? ?????? ?????????????? ???????????? ?????????????????? ?? ???????????????????????????? ???????????????????? ???????????????? ???????????????????????????? ???????????????????? ???? ??????????????????????, ???? ???????????????? ???????? ?????????????????????????? ???????????????????????????????? ???????????????????? ?????????
openaire   +1 more source

?????????????? ???????????????????? ??????????-?????????????????????? ???? ???????????????? IL-1?? ?? ?????????????? ?????????????????? ?? ??????????????????

2015
We have investigated the effect of systemic therapy of obesity on regulation of cytokine IL-1?? synthesis in psoriasis patients produced by healthy donors??? keratinocytes through mononuclear leukocytes (leptin-induced) in vitro. It has been shown that the treatment course with use of acarbose results in a statistically significant reduction or ...
openaire   +1 more source