Results 211 to 220 of about 34,732,115 (289)

Refractory recurrent pericarditis associated with MEFV E148Q variant: selective response to IL-1 receptor antagonism. [PDF]

EULAR Rheumatol Open
Haider SW.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Toll/IL-1 receptor domain-containing adaptor protein plays a crucial role in macrophage-mediated hepatic stellate cell activation in alcoholic liver disease. [PDF]

Front Cell Dev Biol
Patidar P, Obukhov AG, Tasduq SA, Saso L, Baig MS.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

93. Plastic and Reconstructive Surgery’s Economic and Operational Role in Multidisciplinary Care: A Single-center Review of Revenue and Contribution Margins

Plastic and Reconstructive Surgery, Global Open
Annie Fritsch, BS, Jubril Adepoju, BS, Aaron N. Hendizadeh, MS, John A Toms, III, MS, Valerie Pittman, CHFP, Taylor Hilderbrand, MHA, Kathleen Wright, MBA, MHA, Loren Schechter, MD, David Kurlander, MD, David Greenspun, MD, George Kokosis, MD   +10 more
doaj   +1 more source

Correction: TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report. [PDF]

Front Immunol
Frontiers Production Office.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

IL-1 receptor antagonist as a diagnostic biomarker for bacterial infections in acute decompensation of cirrhosis. [PDF]

Sci Rep
Konstantis G, Schütte A, Jung B, Passenberg M, Jacquet L, Guntlisbergen C, Nuruzade N, Hoyer DP, Best J, Willuweit K, Schmidt HH, Guckenbiehl S, Rashidi-Alavijeh J.   +12 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

32. The Value of the Independent Program Training Pathway

Plastic and Reconstructive Surgery, Global Open
Ariel E. Figueroa, MD, Umer Qureshi, MEd, Taylor Hallman, Jason Zhang, MD, Arun K. Gosain, MD   +4 more
doaj   +1 more source