Results 211 to 220 of about 1,896,687 (246)
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The Journal of Immunology, 1990
Abstract IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or ...
Schindler, R, Ghezzi, P, Dinarello, C A
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Abstract IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or ...
Schindler, R, Ghezzi, P, Dinarello, C A
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IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.
The Journal of Immunology, 1988Abstract IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory diseases. We have recently shown that IL-1 induces its own gene expression and, in the present studies, we have examined the effect of IFN-gamma on IL-1-induced IL-1 production. Whereas IFN-gamma increases the total amount of IL-
Ghezzi, P, Dinarello, C A
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The Journal of Immunology, 1994
Abstract These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experiments, in which the ligands bound to immobilized sIL-1R, and in inhibition ...
W P, Arend +7 more
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Abstract These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experiments, in which the ligands bound to immobilized sIL-1R, and in inhibition ...
W P, Arend +7 more
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Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity
Cellular Immunology, 1992Previous work from our laboratory has shown that rabbit articular chondrocytes, like macrophages, produce reactive oxygen intermediates, express Ia antigen, and can mediate immunologic functions such as antigen presentation and induction of mixed and autologous lymphocyte reactions.
K, Tiku +3 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1993
It is hypothesized that the somnogenic and pyrogenic effects of muramyl dipeptide (MDP) are mediated via enhanced interleukin-1 (IL-1) production. To test this hypothesis the effects of intracerebroventricular (icv) administration of a recombinant human soluble type I IL-1 receptor (sIL-1r) and of the IL-1 receptor antagonist (IL-1ra) on MDP-induced ...
L. IMERI, M. OPP, J. KRUEGER
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It is hypothesized that the somnogenic and pyrogenic effects of muramyl dipeptide (MDP) are mediated via enhanced interleukin-1 (IL-1) production. To test this hypothesis the effects of intracerebroventricular (icv) administration of a recombinant human soluble type I IL-1 receptor (sIL-1r) and of the IL-1 receptor antagonist (IL-1ra) on MDP-induced ...
L. IMERI, M. OPP, J. KRUEGER
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American Journal of Reproductive Immunology, 2001
The interleukin‐1 (IL‐1) system has been suggested to be involved in the cell–cell cross talk within the testis. To identify a testicular cell source of IL‐1 alpha, IL‐1 beta and IL‐1 receptor antagonist (IL‐1ra), immature mouse Sertoli cells were isolated, purified, cultured and examined for the cellular compartment localization of these cytokines by ...
M. HULEIHEL +16 more
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The interleukin‐1 (IL‐1) system has been suggested to be involved in the cell–cell cross talk within the testis. To identify a testicular cell source of IL‐1 alpha, IL‐1 beta and IL‐1 receptor antagonist (IL‐1ra), immature mouse Sertoli cells were isolated, purified, cultured and examined for the cellular compartment localization of these cytokines by ...
M. HULEIHEL +16 more
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IL-1 as a target in inflammation
Endocrine, Metabolic & Immune Disorders-Drug Targets, 2015Inflammation is a protective response to eliminate cytotoxic agents and pathogens. Various factors are thought to be involved in the pathological changes in tissues caused by inflammation. Interleukin 1, an inflammatory cytokine, is thought to have diverse physiological functions and to play an important role in inflammatory disease. In this review, we
Yuki, Ito +5 more
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Induction of IL-1: independent production of IL-1 alpha and IL-1 beta.
Cytokine, 1992Lipopolysaccharide (LPS) either in its soluble form or associated with multilamellar phospholipid vesicles (liposomes) was investigated for its ability to induce human monocyte interleukin (IL)-1 alpha and IL-1 beta. When human monocytes were activated in vitro by LPS either in its soluble form or presented at the surface of lyophilized multilamellar ...
O, Bakouche, J L, Moreau, L B, Lachman
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Nature Immunology, 2015
Direct antagonism between interleukin1 (IL-1) and the vitamin A metabolite retinoic acid tips the balance between differentiation into the TH17 subset of helper T cells or into regulatory T cells by influencing the transcription factors STAT3 and STAT5.
Alejandro V Villarino, Arian Laurence
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Direct antagonism between interleukin1 (IL-1) and the vitamin A metabolite retinoic acid tips the balance between differentiation into the TH17 subset of helper T cells or into regulatory T cells by influencing the transcription factors STAT3 and STAT5.
Alejandro V Villarino, Arian Laurence
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IL-1 induces rapid phosphorylation of the IL-1 receptor.
The Journal of Immunology, 1989Abstract The IL-1R on murine T cells is a Mr = 80,000 plasma membrane glycoprotein. cDNA cloning and transfection experiments have shown that this is an integral membrane protein, which binds both IL-1 alpha and IL-1 beta and transduces the IL-1 signal.
B, Gallis +6 more
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