Results 211 to 220 of about 111,339,475 (290)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

IL-1-mediated vitreous inflammation as an early indicator of retinal ganglion cell loss following acute optic nerve injury. [PDF]

J Neuroinflammation
Chang S, Fan W, Wu J, Xu L, Lee VA, Zhang C, Kronenberg EP, Xu W, Yang H, Zhang HF, Liu X.   +10 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Adult-onset chronic nonbacterial osteitis mimicking refractory axial psoriatic arthritis: successful treatment with combined IL-1/IL-17 inhibition: a case report and brief literature review. [PDF]

EULAR Rheumatol Open
Karakoc A, Wirsching A, Bucci L, Corte G, Atzinger A, Schett G, Fagni F.   +6 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

93. Plastic and Reconstructive Surgery’s Economic and Operational Role in Multidisciplinary Care: A Single-center Review of Revenue and Contribution Margins

Plastic and Reconstructive Surgery, Global Open
Annie Fritsch, BS, Jubril Adepoju, BS, Aaron N. Hendizadeh, MS, John A Toms, III, MS, Valerie Pittman, CHFP, Taylor Hilderbrand, MHA, Kathleen Wright, MBA, MHA, Loren Schechter, MD, David Kurlander, MD, David Greenspun, MD, George Kokosis, MD   +10 more
doaj   +1 more source

The effect of IL-1 blockers on exertional leg pain in familial Mediterranean fever patients: an exploratory study. [PDF]

Rheumatology (Oxford)
Druyan A, Livneh A, Giat E, Ben-Zvi I, Lidar M.   +4 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

IL-1 signaling and inflammasomes in acute myeloid leukemia: mechanisms and therapeutic opportunities. [PDF]

Cell Mol Life Sci
Mortellaro A, Mastaglio S, Muzio M.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source