Results 231 to 240 of about 34,732,115 (289)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

74. Comparative Analysis of Acellular Dermal Matrices as Vehicle for Stem Cell Therapy Delivery

Plastic and Reconstructive Surgery, Global Open
Margaret W. Lieb, MD, MS, Calvin A. Korba, MD, Michelle Randle, MS, Carrie E. Harrison, BS, Michael W. Neumeister, MD   +4 more
doaj   +1 more source

Levels of IL-1β and IL-1 receptor antagonist (IL-1Ra) in Moroccan children admitted to the pediatric emergency department for febrile seizures. [PDF]

BMC Pediatr
Abbari I, Missaoui S, Kholaiq H, Benbouziane N, Aadam Z, Abderrahmane E, El Bakkouri J, Bousfiha AA, Gueddari W.   +8 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

D136. Role of Anterior Scalene Muscle Block in Predicting Outcomes in Rib-sparing Vs. First Rib Resection Techniques For Thoracic Outlet Syndrome

Plastic and Reconstructive Surgery, Global Open
Iulianna Taritsa, BA, Kazimir Bagdady, BS, Rushmin Khazanchi, BA, Cristin Coquillard, MD, Rolando Casas Fuentes, BS, Timothy Burke, BA, Puja Jagasia, BA, Lindsay Janes, MD, Ashley Vavra, MD, Jason H. Ko, MD, MBA, FACS   +9 more
doaj   +1 more source

Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. [PDF]

Mol Ther
Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH.   +11 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

D24. Financial Toxicity Associated With Cleft Palate Repair: A Survey of Family Financial Well-being

Plastic and Reconstructive Surgery, Global Open
Sophia Allison, BA, Hannah Soltani, BA, Emily Chwa, BS, Rachel Donaldson, BS, Arun Gosain, MD   +4 more
doaj   +1 more source

Engineered cationic Interleukin-1 receptor antagonist outperforms anakinra at joint retention and preventing IL-1-induced cartilage inflammation. [PDF]

Osteoarthritis Cartilage
Boyer TL, Hakim B, Childress L, Baby HM, Porter RM, Bajpayee AG.   +5 more
europepmc   +1 more source