Results 251 to 260 of about 2,185,989 (294)

Targeting IL-1 controls refractory pityriasis rubra pilaris. [PDF]

Sci Adv
Schmauch E, Severin Y, Xing X, Mangold A, Conrad C, Johansen P, Kahlenberg JM, Mellett M, Navarini A, Nobbe S, Sarkar MK, Satyam A, Tsoi LC, French LE, Nilsson J, Linna-Kuosmanen S, Kaikkonen MU, Snijder B, Kellis M, Gudjonsson JE, Tsokos GC, Contassot E, Kolios AGA.   +22 more
europepmc   +1 more source

The Role of TSLP and IL-1 β and Their Genetic Variants in the Pathogenesis of Single and Multiple Atopic Diseases in Children. [PDF]

J Clin Med
Sikorska-Szaflik H, Dębińska A, Połomska J, Drabik-Chamerska A, Sozańska B.   +4 more
europepmc   +1 more source

Identification of RP-54745, an IL-1 Inhibitor Displaying Anticancer Activities for KSHV-Related Primary Effusion Lymphoma. [PDF]

J Med Virol
Dai L, Choudhary A, Fan J, Huang L, Lin Z, Qin Z.   +5 more
europepmc   +1 more source

IL-1 Receptor Antagonist Anakinra Inhibits the Effect of IL-1β- Mediated Osteoclast Formation by Periodontal Ligament Fibroblasts. [PDF]

Biology (Basel)
Steemers E, Talbi WMI, Hogervorst JMA, Schoenmaker T, de Vries TJ.   +4 more
europepmc   +1 more source

Correction: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. [PDF]

Biochem J
europepmc   +1 more source

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IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

The Journal of Immunology, 1990
Abstract IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial cells. IL-1-induced IL-1 may be part of a self-amplification or an autocrine growth factor in a variety of responses, and thus the endogenous regulation of IL-1 production likely contributes to the outcome of immunologic or ...
Schindler, R, Ghezzi, P, Dinarello, C A
openaire   +3 more sources

IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma.

The Journal of Immunology, 1988
Abstract IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory diseases. We have recently shown that IL-1 induces its own gene expression and, in the present studies, we have examined the effect of IFN-gamma on IL-1-induced IL-1 production. Whereas IFN-gamma increases the total amount of IL-1 (
Ghezzi, P, Dinarello, C A
openaire   +3 more sources

Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity

Cellular Immunology, 1992
Previous work from our laboratory has shown that rabbit articular chondrocytes, like macrophages, produce reactive oxygen intermediates, express Ia antigen, and can mediate immunologic functions such as antigen presentation and induction of mixed and autologous lymphocyte reactions.
K, Tiku, S, Thakker-Varia, A, Ramachandrula, M L, Tiku   +3 more
openaire   +2 more sources

Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.

The Journal of Immunology, 1994
Abstract These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experiments, in which the ligands bound to immobilized sIL-1R, and in inhibition ...
W P, Arend, M, Malyak, M F, Smith, T D, Whisenand, J L, Slack, J E, Sims, J G, Giri, S K, Dower   +7 more
openaire   +2 more sources