Results 141 to 150 of about 77,313,502 (292)
, 2019 The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the first
Martin Thurnher (7175114) +7 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Estudo da atividade antiinflamatória dos ligantes do receptor periférico dos benzodiazepínicos: Pk11195 e Ro5-4864 [PDF]
, 2001 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências BiológicasO tratamento in vivo em camundongos com ligantes do receptor periférico benzodiazepínico (PBR) exerceram efeito inibitório na resposta inflamatória em dois ...
Torres, Sandra Regina Rachadel
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]
, 2011 We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane +10 more
core
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Regulatory mechanisms inhibiting anti-mycobacterial immunity following Mycobacterium tuberculosis infection. [PDF]
, 2007 The work reported in this thesis addresses the regulatory factors that function to limit the initiation of protective immune responses following exposure to the bacterium Mycobacterium tuberculosis (MTb). Control and clearance of intracellular pathogens,
Redford, P.S.
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy. [PDF]
J Neuroinflammation, 2020 Runge EM +5 more
europepmc +1 more source