Results 251 to 260 of about 1,026,832 (278)

Identification of potential hub genes and drugs in septic liver injury: A bioinformatic analysis. [PDF]

Medicine (Baltimore)
Yang Y, Lv J, Chu J, Song G, Sun S, Chen R.   +5 more
europepmc   +1 more source

Tumor-Associated Macrophages in Hepatocellular Carcinoma: From Ontogeny and Heterogeneity to Immune Evasion and Therapeutic Targeting. [PDF]

J Hepatocell Carcinoma
Su Y, Liang Y, Zhong D, Chen Y, Ma SS, Huang X.   +5 more
europepmc   +1 more source

Possible association of schizophrenia with variants of the IL-10 receptor 1

European Psychiatry, 2004
openaire   +1 more source

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IL‐10 and IL‐10 receptor defects in humans

Annals of the New York Academy of Sciences, 2011
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is chronic in nature and is characterized by abdominal pain, diarrhea, bleeding, and malabsorption. It is considered a complex multigenic and multifactorial disorder that results from disturbed interactions between the immune system and commensal bacteria
Erik-Oliver, Glocker, Daniel, Kotlarz, Christoph, Klein, Neil, Shah, Bodo, Grimbacher   +4 more
openaire   +2 more sources

The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor

The Journal of Immunology, 1997
Abstract BCRF1 is an EBV homologue of human IL-10 (hIL-10) and is known as viral IL-10 (vIL-10). As found earlier for the effects of vIL-10 on mouse mast cells and CD4+ T cells, the efficiency of inhibition by vIL-10 of IL-2 production by human CD4+ T cell clones is approximately 1000-fold diminished compared with hIL-10.
Y, Liu, R, de Waal Malefyt, F, Briere, C, Parham, J M, Bridon, J, Banchereau, K W, Moore, J, Xu   +7 more
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Identification and characterization of a human IL-10 receptor antagonist

Human Immunology, 2013
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that works through IL-10 receptor alpha subunit- and suppresses immune responses in many infectious diseases such as leishmaniasis as well as in cancer. Therefore, in order to restore the host-protective immune responses in such diseases, an antagonist to this cytokine is a pressing need.
Mohammed Mumtaz, Naiyer, Shipra, Saha, Vijayshree, Hemke, Somenath, Roy, Shailza, Singh, Krishnasastry V, Musti, Bhaskar, Saha   +6 more
openaire   +2 more sources

IL-10 in Humans: Lessons from the Gut, IL-10/IL-10 Receptor Deficiencies, and IL-10 Polymorphisms

2014
Inflammatory bowel disease (IBD) represents a heterogeneous group of gastrointestinal disorders, where commensal gut flora provokes an either (a) insufficient or (b) uncontrolled immune response. This results either in a lack of or in excessive inflammation mainly manifesting as Crohn's disease or ulcerative colitis.
Engelhardt, Karin R., Grimbacher, Bodo
openaire   +3 more sources

IL-10 receptor dysfunction in macrophages during chronic inflammation

Journal of Leukocyte Biology, 2001
AbstractThe immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells.
R, Avdiushko, D, Hongo, H, Lake-Bullock, A, Kaplan, D, Cohen   +4 more
openaire   +2 more sources