Results 261 to 270 of about 1,026,832 (278)

Identification of grass carp IL-10 receptor subunits: Functional evidence for IL-10 signaling in teleost immunity

Developmental & Comparative Immunology, 2014
Although the functions of teleost IL-10 have been preliminarily determined, functional evidence for its receptor signaling is lacking. Particularly, the identity of fish IL-10 receptor 2 (IL-10R2) is ambiguous. Cytokine receptor family member b4 (CRFB4) and CRFB5 are likely the ortholog of mammalian IL-10R2.
He, Wei, Xinyan, Wang, Anying, Zhang, Linyong, Du, Hong, Zhou   +4 more
openaire   +2 more sources

Biological Roles of IL-10 and the CD40 Receptor

1993
The immune response is regulated by soluble and membrane-associated glycoproteins produced by a variety of hemopoietic and non-hemopoietic cells. We focus here on examples of each of these types of immune regulators. IL-10 is a soluble protein produced by helper T cells, macrophage/monocytes, and B cells, which exhibits a wide array of both ...
M. C. Howard, A. W. Heath, H. Ishida, K. W. Moore   +3 more
openaire   +1 more source

Expression cloning and characterization of a human IL-10 receptor.

The Journal of Immunology, 1994
Abstract cDNA clones encoding a human IL-10R (hIL-10R) from a Burkitt lymphoma cell line, BJAB, express a 90 to 110 kDa polypeptide in COS7 cells that binds hIL-10 specifically. The predicted amino acid sequence of hIL-10R is 60% identical and 73% similar to mouse IL-10R (mIL-10R).
Y, Liu, S H, Wei, A S, Ho, R, de Waal Malefyt, K W, Moore   +4 more
openaire   +2 more sources

RNA aptamer against the IL-10 receptor block IL-10 function in vitro and in vivo (66.46)

The Journal of Immunology, 2011
Abstract IL-10 is a key mediator of immune suppression in malignancies and during chronic infections. In mice, the inability of the immune system to clear viral infections and tumor growth can be reversed by antibody-mediated blockade of IL-10 action.
Alexey Berezhnoy, Charles Stewart, Paloma Giagrande, James McNamara, Giorgio Trinchieri, Eli Gilboa   +5 more
openaire   +1 more source

Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys

Nature Immunology, 2000
As originally demonstrated for the interleukin 1 (IL-1) type II receptor, some primary proinflammatory cytokines from the IL-1 and tumor necrosis factor families are regulated by decoy receptors that are structurally incapable of signaling. Here we report that concomitant exposure to proinflammatory signals and IL-10 generates functional decoy ...
G, D'Amico, G, Frascaroli, G, Bianchi, P, Transidico, A, Doni, A, Vecchi, S, Sozzani, P, Allavena, A, Mantovani   +8 more
openaire   +2 more sources

Differential expression of IL‐10 receptor by epithelial cells and alveolar macrophages

Allergy, 2004
Background:  Interleukin (IL)‐10 is a pleiotropic cytokine with a broad spectrum of immunosuppressive and anti‐inflammatory effects. IL‐10 secretion from alveolar macrophages is defective in patients with asthma and lower concentrations of IL‐10 are found in bronchoalveolar lavage (BAL) from asthmatic patients than in normal control subjects.
LIM S, CARAMORI, Gaetano, TOMITA K, JAZRAWI E, OATES T, CHUNG KF, BARNES PJ, ADCOCK IM   +7 more
openaire   +5 more sources

Expression of the IL-10 receptor on human monocytes is moderately suppressed by glucocorticoids

International Immunopharmacology, 2002
Chemicals/CAS: Dexamethasone, 50-02-2; Receptors, Interleukin; Receptors, Interleukin-10.
Visser, J., Nagelkerken, L.
openaire   +4 more sources

Reduced IL‐10 production and ‐receptor expression in neonatal T lymphocytes

Acta Paediatrica, 2007
AbstractAim: To further evaluate the underlying mechanism of a formerly demonstrated immature anti‐inflammatory response in neonates (1).Methods: Interleukin (IL)‐10 production was measured by enzyme‐linked immunosorbent‐assay (ELISA) after anti‐CD3/anti‐CD28 costimulation of neonatal and adult T cells.
C, Schultz, T, Strunk, P, Temming, N, Matzke, C, Härtel   +4 more
openaire   +2 more sources

The transition to the metastatic phenotype of rat lymphoma cells involves up-regulation of IL-10 receptor expression and IL-10 secretion

Clinical & Experimental Metastasis, 2005
Interleukin 10 (IL-10) is a Th2 anti-inflammatory cytokine that participates in the regulation of the immune response at several levels. Its production has been implicated in the immunosuppression frequently observed in tumor bearing hosts. The broad spectrum of IL-10 biologic activities is mediated by its binding to its cognate receptor (IL-10R).
María José, Rico, Pablo, Matar, Silvia I, Gervasoni, R Daniel, Bonfil, Nora, Calcaterra, O Graciela, Scharovsky   +5 more
openaire   +2 more sources

The B cell IL-10 receptor suppresses antibody production.

The Journal of Immunology, 2018
Abstract Generation of high affinity, broadly neutralizing antibodies has remained a holy grail in influenza and malaria. Appropriate B cell responses are essential for producing neutralizing antibodies to combat these infections. Additionally, cytokines and their receptors are known to orchestrate the immune response to infections on ...
Abigail Dooley, Montserrat Quintana, Michael Cheung, Li Lauren Sun, Neetu Gupta   +4 more
openaire   +1 more source