Results 201 to 210 of about 1,780,060 (243)

An oncolytic herpes simplex virus armed with IL-12 for treatment of preclinical glioblastoma. [PDF]

Mol Ther Oncol
Jackson JW, Hall BL, Sneiderman C, Webb A, Hancock TJ, Vlasyuk M, Bailey L, Xiaokui M, Solomon IH, Ligon K, Goins WF, Kohanbash G, Chiocca EA, Glorioso JC.   +13 more
europepmc   +1 more source

Retraction for Kundu et al., Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Assessment of Fecal Microbiota in Healthy Dogs and Dogs with Cutaneous Mast Cell Tumors Treated with Electrochemotherapy Combined with Gene Electrotransfer of IL-12. [PDF]

Vet Sci
Lisjak A, Correa Lopes B, Pilla R, Nemec A, Lampreht Tratar U, Suchodolski JS, Tozon N.   +6 more
europepmc   +1 more source

De-coupling immune parameters and toxicity associated with IL-12 agonism. [PDF]

Cell Rep
Lanzar ZR, Aldridge DL, Jayaraman B, Haskins B, Howard CA, Arana K, Bunkofske ME, Mulka K, Pardy RD, Byerly J, Striepen B, Lupardus P, Hunter CA.   +12 more
europepmc   +1 more source

IL-12-armed oncolytic HSV-2 enhances CAR T cell efficacy against pancreatic cancer in xenografted models. [PDF]

Front Immunol
Xu C, Wu J, Liu W, Zhou X, Liang Q, Li G, Wang Y, Liu Y, Cai Q, Tang Z, Tu C, Hu H, Liu B, Meng S.   +13 more
europepmc   +1 more source

Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity. [PDF]

Mol Ther
Lunavat TR, Nieland L, van de Looij SM, de Reus AJEM, Couturier CP, El Farran CA, Miller TE, Lill JK, Schübel M, Xiao T, Di Ianni E, Woods EC, Sun Y, Rufino-Ramos D, van Solinge TS, Mahjoum S, Grandell E, Li M, Mangena V, Dunn GP, Jenkins RW, Mempel TR, Breakefield XO, Breyne K.   +23 more
europepmc   +1 more source

The Role and Potential Application of IL-12 in the Immune Regulation of Tuberculosis. [PDF]

Int J Mol Sci
Wang H, Ruan G, Li Y, Liu X.
europepmc   +1 more source

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IL-12 ELISPOT ASSAYS TO DETECT AND ENUMERATE IL-12 SECRETING CELLS

Cytokine, 2000
The cytokine IL-12 promotes Th(1)type immune responses and plays a key role in immune regulation. The complex nature of IL-12 hampered its detection without use of stimulants that might give less relevant information. To detect circulating IL-12 p40, we developed enzyme-linked immunospot (ELISPOT) assays that allow enumeration of IL-12 p40 secreting ...
Ozenci, V, Kouwenhoven, M, Press, R, Link, H, Huang, Y M   +4 more
openaire   +3 more sources

Nanocapsule Delivery of IL-12

2020
Interleukin(IL)-12 is a protein that activates T cells and macrophages to kill tumor cells. However, despite this cytokine showing strong antitumor activity in preclinical settings, translation to patients has been slowed by toxic side effects, poor distribution to peripheral tissues, and improper dosing regimens.
Justin E, Markel, Ryan A, Lacinski, Brock A, Lindsey   +2 more
openaire   +2 more sources

Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity

International Immunopharmacology, 2003
Interleukin-12 (IL-12) is a heterodimeric cytokine that enhances immune responses to bacterial, parasitic, and viral pathogens, and leads to tumor regression in animal models. For this reason, the use of IL-12 as a vaccine adjuvant and as a therapeutic agent for the treatment of cancer is being investigated.
Victor C, Huber, Bernard P, Arulanandam, Paul M, Arnaboldi, Monica K, Elmore, Christine E, Sheehan, Bhaskar V S, Kallakury, Dennis W, Metzger   +6 more
openaire   +2 more sources