Results 201 to 210 of about 1,721,070 (243)

Tumor-Targeted IL-12 (PDS01ADC) with Hepatic Artery Infusion Pump Therapy for Colorectal Liver Metastases: Interim Analysis of a Non-randomized Phase II Trial. [PDF]

JCO Oncol Adv
Eade AV, Smith EC, Monge C, Hannah CE, Skorupan N, Hrones DM, Celades C, Goswami M, Bagheri H, Smith KM, Rainey AJ, Friedman LR, Larrain C, Pu T, Sinha S, Desai PP, Remmer K, Satterwhite AA, Joyce SR, Dinerman AJ, Wood BJ, Kassin MT, Ukeh IN, Blakely AM, Davis JL, Kleiner DE, Lassoued W, Gameiro SR, Donahue RN, Gulley JL, Schlom J, Hernandez JM.   +31 more
europepmc   +1 more source

The ubiquitin-like modifier FAT10 does not affect IL-12 expression and signaling. [PDF]

PLoS One
Cao J, Alvarez Salinas GO, Schmidtke G, Basler M.   +3 more
europepmc   +1 more source

EFFECTIVENESS AND SAFETY OF SELECTIVE IL-12/23 RECEPTOR ANTAGONISTS IN MODERATE TO SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW, META-ANALYSIS AND TRIAL SEQUENTIAL ANALYSIS. [PDF]

Arq Gastroenterol
Amador WFO, Vitor IC, Tomé MR, Dotta DD, Motta RV.   +4 more
europepmc   +1 more source

IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy. [PDF]

Front Immunol
Liu Z, Li H, Gao Z, Cheng R, Lu J, Che X, Dong J, Wang Z, Cui Z, Gu J, Bai Y, Li C, Liu Y, Wang C, Deng H.   +14 more
europepmc   +1 more source

Oncolytic HSV-1 expressing GM-CSF and IL-12 enhances anti-tumor efficacy in immunocompetent murine melanoma model. [PDF]

Virol Sin
Xiao H, Yin Q, Liu J, Hu H, Li J, Wang M, Hu Z.   +6 more
europepmc   +1 more source

Retraction: Functional Changes of Dendritic Cells in C6 Glioma-Bearing Rats That Underwent Combined Argon-Helium Cryotherapy and IL-12 Treatment. [PDF]

Technol Cancer Res Treat
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IL-12 ELISPOT ASSAYS TO DETECT AND ENUMERATE IL-12 SECRETING CELLS

Cytokine, 2000
The cytokine IL-12 promotes Th(1)type immune responses and plays a key role in immune regulation. The complex nature of IL-12 hampered its detection without use of stimulants that might give less relevant information. To detect circulating IL-12 p40, we developed enzyme-linked immunospot (ELISPOT) assays that allow enumeration of IL-12 p40 secreting ...
Ozenci, V, Kouwenhoven, M, Press, R, Link, H, Huang, Y M   +4 more
openaire   +3 more sources

Nanocapsule Delivery of IL-12

2020
Interleukin(IL)-12 is a protein that activates T cells and macrophages to kill tumor cells. However, despite this cytokine showing strong antitumor activity in preclinical settings, translation to patients has been slowed by toxic side effects, poor distribution to peripheral tissues, and improper dosing regimens.
Justin E, Markel, Ryan A, Lacinski, Brock A, Lindsey   +2 more
openaire   +2 more sources

Delivery of IL-12 intranasally leads to reduced IL-12-mediated toxicity

International Immunopharmacology, 2003
Interleukin-12 (IL-12) is a heterodimeric cytokine that enhances immune responses to bacterial, parasitic, and viral pathogens, and leads to tumor regression in animal models. For this reason, the use of IL-12 as a vaccine adjuvant and as a therapeutic agent for the treatment of cancer is being investigated.
Victor C, Huber, Bernard P, Arulanandam, Paul M, Arnaboldi, Monica K, Elmore, Christine E, Sheehan, Bhaskar V S, Kallakury, Dennis W, Metzger   +6 more
openaire   +2 more sources