Results 211 to 220 of about 1,721,070 (243)
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Current Cancer Drug Targets, 2017
Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.In this review, we describe the structural features of IL-12 family and their roles involved in cancer.IL-12 has been demonstrated to ...
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Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.In this review, we describe the structural features of IL-12 family and their roles involved in cancer.IL-12 has been demonstrated to ...
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2016
Interleukin 12 (IL-12) is a heterodimeric, multifunctional cytokine, the actions of which orchestrate activities of innate and adaptive immunity, partially due to a potent stimulation of IFN-γ production from T lymphocytes and natural killer (NK) cells.
Radoslaw Zagozdzon, Witold Lasek
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Interleukin 12 (IL-12) is a heterodimeric, multifunctional cytokine, the actions of which orchestrate activities of innate and adaptive immunity, partially due to a potent stimulation of IFN-γ production from T lymphocytes and natural killer (NK) cells.
Radoslaw Zagozdzon, Witold Lasek
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Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist
European Journal of Immunology, 1995AbstractInterleukin‐12 (IL‐12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide‐bonded subunits, p40 and p35. It was recently reported that supernatants from cultures of mouse IL‐12 (moIL‐12) p40‐transfected COS cells could inhibit IL‐12‐dependent responses in vitro (Mattner, F., et al., Eur.
S, Gillessen +9 more
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Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness
The Journal of Immunology, 1998Abstract Regulation of the factors governing IL-12R expression and IL-12 responsiveness has been shown to be important in the generation and stability of Th1- and Th2-type responses. In this regard, cytokines have been shown to have a prominent role in regulating IL-12R expression.
C Y, Wu +3 more
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Cloning and expression of murine IL-12
The Journal of Immunology, 1992Abstract Human IL-12 (NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that can act as a growth factor for activated human T and NK cells, enhance the lytic activity of human NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting human PBMC. Because in our
D S, Schoenhaut +8 more
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IL-12 Is a Heparin-Binding Cytokine
The Journal of Immunology, 1999Abstract Using an ELISA approach, we demonstrate that recombinant human IL-12 (rhIL-12) binds strongly to an immobilized heparin-BSA complex. This binding is completely displaceable with soluble heparin, IC50∼ 0.1 μg/ml, corresponding to ∼ 10 nM.
M, Hasan +4 more
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Inhibition of IL-12 production by thalidomide
The Journal of Immunology, 1997Abstract The immunomodulatory properties of thalidomide are currently being exploited therapeutically in conditions as diverse as erythema nodosum leprosum, chronic graft-vs-host disease, rheumatoid arthritis, and sarcoidosis. The relevant mechanism of action of thalidomide in these diseases remains unclear.
D R, Moller +7 more
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