Results 211 to 220 of about 1,581,460 (288)

Phospho-Proteomic Analysis of Interleukin-13 Signaling in Airway Cells Reveals SRC Family Kinase Involvement in Interleukin-13-Induced Inflammatory Responses. [PDF]

Int Arch Allergy Immunol
Shankar A, McAlees JW, Wyder MA, Hargis JM, Ediga HH, Cannata A, Latayan J, Greis KD, Madala SK, Lewkowich IP.   +9 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Serum IL-18/IL-13 Ratio Predicts Super Response to Secukinumab in Patients with Psoriasis. [PDF]

Int J Mol Sci
Ziolkowska-Banasik D, Pastuszczak M, Zawadzinska-Halat K, Hadas E, Bozek A.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

RETRACTION: HDAC4 Depletion Ameliorates IL-13-Triggered Inflammatory Response and Mucus Production in Nasal Epithelial Cells via Activation of SIRT1/NF-κB Signaling. [PDF]

Immun Inflamm Dis
europepmc   +1 more source

IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting ACE2-mediated virus binding and cell entry. [PDF]

Immunohorizons
Pivniouk V, Pivniouk O, Uhrlaub JL, Hahn S, Molzahn A, Kimura H, Numata M, Chu HW, Ledford JG, Kraft M, Nikolich JŽ, Vercelli D.   +11 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Airway sympathectomy attenuates inflammation, transcriptional ratios of Muc5ac and Muc5b, and airway mechanic deficits in mice delivered intranasal IL-13. [PDF]

Am J Physiol Lung Cell Mol Physiol
Trevizan-Baú P, Fagan AL, Amin SP, Reznikov LR.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD. [PDF]

Respir Res
Staples KJ, Ackland J, Lukose S, Angermann B, Belfield G, Belvisi M, Chaerkady R, Etal D, Heinson A, Hess S, Hristova VA, Hühn M, McCrae C, Muthas D, Öberg L, Ostridge K, Platt A, Spalluto CM, Watson A, Wilkinson T, MICAII study group.   +20 more
europepmc   +1 more source