Results 131 to 140 of about 5,540,448 (336)

Assessment of The Impact of Apremilast on Levels of IL-17, IL-23, and Lipids in Obese Psoriatic Patient

مجلة كلية الطب
Background: Psoriasis is an immune-mediated inflammatory disease with unknown aetiology that may be associated with the defect in proliferation and differentiation of the keratinocytes related to inflammatory cell infiltration.
Haitham M. Saad, Adil A. Noaimi, Halla Gh. Mahmood   +2 more
doaj   +1 more source

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Immunity, 2006
M. Veldhoen, R. J. Hocking, C. Atkins, R. Locksley, B. Stockinger   +4 more
semanticscholar   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

ILC3 Function as a Double-Edged Sword in EV71 Infection

Viruses
Enterovirus 71 (EV71) is a common pathogen responsible for hand, foot, and mouth disease (HFMD), leading to severe neurological complications and even death.
Chang Zhang, Linlin Bao, Feifei Qi, Qi Lv, Fengdi Li, Chuan Qin   +5 more
doaj   +1 more source

IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines [PDF]

, 2001
Sophie Molet, Qutayba Hamid, Francis Davoineb, Esra Nutku, Rame Tahaa, Nathalie Pagé, Ron Olivenstein, Jack A. Elias, Jamila Chakir   +8 more
openalex   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1 [PDF]

, 2001
James Lee, Wei-Hsien Ho, Miko Maruoka, Racquel Corpuz, Daryl T. Baldwin, Jessica Foster, Audrey D. Goddard, Daniel G. Yansura, Richard Vandlen, William I. Wood, Austin Gurney   +10 more
openalex   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

IL-17 Mobilizes Peripheral Blood Stem Cells with Short- and Long-Term Repopulating Ability in Mice [PDF]

, 2001
Paul Schwarzenberger, Weitao Huang, Peter Oliver, P. S. Byrne, Vincent La Russa, Zili Zhang, Jay K. Kolls   +6 more
openalex   +1 more source

Characterization of IL-17 and IL-17 receptor families in lampreys

Frontiers in Immunology, 2013
Cooper Max, Han Qifeng, Hirano Masayuki
openaire   +2 more sources