Results 141 to 150 of about 1,534,063 (244)

Could the IL-17 cytokine family be a promising target for the treatment of palmoplantar pustulosis? [PDF]

J Eur Acad Dermatol Venereol
Mrowietz U, Gerdes S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

T cells are critical for pre-metastatic niche formation through the STAT3/IL-17 axis. [PDF]

J Immunother Cancer
Kujawski M, Martincuks A, Song M, Zhang C, Huang R, Wang T, Senguttuvan R, Nakamura B, Palmer M, Bacon ER, Ihle K, Forman SJ, Shively JE, Rodriguez-Rodriguez L, Priceman SJ, Yu H.   +15 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

NMI promotes the secretion of IL-17 and exacerbates psoriasis. [PDF]

Proc Natl Acad Sci U S A
Gao Y, Wang J, Qin Z, Xu N, Wang X, Liu T, Wang S, Chen Z, Xu Y, Yao Y, Wu Y, Weng Z, Geng Y, Yin Z, Qin J, Xu T, Liu Y, Liang H.   +17 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans. [PDF]

Nat Commun
Kakade P, Burgueno JF, Sircaik S, Ponde NO, Li J, Ene IV, Kim J, Liang SH, Yunker R, Dey I, Akiba Y, Vaishnava S, Kaunitz JD, Way SS, Koh AY, Gaffen SL, Abreu MT, Bennett RJ.   +17 more
europepmc   +1 more source

Characterization of IL-17 and IL-17 receptor families in lampreys

Frontiers in Immunology, 2013
Cooper Max, Hirano Masayuki, Han Qifeng
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Targeting IL-17/NF-κB/VAChT/Rho-kinase signaling and oxidative stress in exacerbated chronic allergic inflammation: functional and therapeutic implications of IL-17 blockade. [PDF]

Braz J Med Biol Res
Camargo LN, Santos TMD, Saraiva-Romanholo BM, Leick EA, Prado CM, Righetti RF, Tibério IFLC.   +6 more
europepmc   +1 more source