Results 251 to 260 of about 1,536,578 (286)

Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium. [PDF]

Commun Biol
Bruce JK, Li LY, Tang Y, Forster E, Winsor NJ, Bi PY, Krustev C, Keely S, Lee JE, Rohde JR, Gaisano HY, Philpott DJ, Girardin SE.   +12 more
europepmc   +1 more source

Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model. [PDF]

Sci Rep
Liu M, Luo Y, Song X, Mo R, Fu J, Fu Q, Li J, Wu J, Wu H, Zhong F, Li H, Liu X, Ni G, Wang T.   +13 more
europepmc   +1 more source

Oncolytic vaccinia virus expressing non-secreted decoy-resistant IL-18 mutein elicits potent antitumor effects with enhanced safety. [PDF]

Mol Ther Oncol
Ye J, Chen L, Patel S, Ming P, Li C, Waltermire J, Zhao J, Ren J, Bartlett DL, Liu Z.   +9 more
europepmc   +1 more source

IL-18 gene polymorphisms affect IL-18 production capability by monocytes.

IL-18 gene polymorphisms affect IL-18 production capability by monocytes.
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IL-18 gene polymorphisms affect IL-18 production capability by monocytes

Biochemical and Biophysical Research Communications, 2006
We previously demonstrated a significant association between IL-18 gene polymorphism 105A/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105A/C and IL-18--137G/C was determined by PCR analyses.
Junsuke, Arimitsu, Toru, Hirano, Shinji, Higa, Mari, Kawai, Tetsuji, Naka, Atsushi, Ogata, Yoshihito, Shima, Minoru, Fujimoto, Tomoki, Yamadori, Keisuke, Hagiwara, Tomoharu, Ohgawara, Yusuke, Kuwabara, Ichiro, Kawase, Toshio, Tanaka   +13 more
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Immunotherapeutic Applications of IL-18

Immunotherapy, 2012
To become active and extracellularly released, IL-18 needs post-translational processing by the cytoplasmic enzyme caspase-1, which has high sequence homology with apoptotic cell death-associated enzymes in Caenorhabditis elegans. Furthermore, the receptor for IL-18 shares the signal transduction pathway with the Toll-like receptor, which highly ...
Hiroko, Tsutsui, Kenji, Nakanishi
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IL-18 and skin inflammation

Autoimmunity Reviews, 2009
IL-18 belongs to the IL-1 family of cytokines and has recently regained interest in the context of inflammasome activation. The inflammasome dependent caspase 1 cleaves pro-IL-18 into the active form - similar to what is known for IL-1ss. Still, the action and importance of IL-18 are not completely understood.
Miriam, Wittmann, Andrew, Macdonald, Julius, Renne   +2 more
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Human Anti–Human IL-18 Antibody Recognizing the IL-18–Binding Site 3 with IL-18 Signaling Blocking Activity

The Journal of Biochemistry, 2005
IL-18 is an important regulator in both innate and acquired immune responses. The aberrant expression of IL-18 is associated with severe inflammatory conditions, such as autoimmune diseases and allergies. Thus, human antibodies with inhibitory activity on IL-18 signaling may be useful for therapeutic applications. We report here the first establishment
Takayuki, Hamasaki, Shuhei, Hashiguchi, Yuji, Ito, Zenichiro, Kato, Kenji, Nakanishi, Toshihiro, Nakashima, Kazuhisa, Sugimura   +6 more
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Distribution of IL-18 and IL-18 receptor in human skin: various forms of IL-18 are produced in keratinocytes

Archives of Dermatological Research, 2001
Human interleukin-18 (IL-18) enhances IL-12-mediated IFN-gamma production by lymphocytes and Fas/perforin-mediated cytolysis by NK cells. IL-18 is synthesized as a 24 kDa proform, and the proform is processed in the cytoplasm into an 18 kDa mature form.
H, Koizumi, K C, Sato-Matsumura, H, Nakamura, K, Shida, S, Kikkawa, M, Matsumoto, K, Toyoshima, T, Seya   +7 more
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