Results 241 to 250 of about 70,619,624 (286)

Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia. [PDF]

Neurosci Bull
Chen H, Jin S, Liu M, Zhu Y, Zhang L, Li C, Liu P, Tong X, Zhu Z.   +8 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity. [PDF]

Mol Ther
Barragán Bravo GA, de la Cerda DA, Landoni E, Dholakia K, Humeniuk P, Caraballo Galva LD, Wang Y, Tian G, Yang B, Guo L, Wood MS, Rios X, Xu X, Courtney AN, Di Pierro EJ, Jacob J, Li YH, Adaikkalavan A, Watanabe N, Mao S, Miles G, Dotti G, Metelitsa LS.   +22 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Serum Levels of the Proinflammatory Cytokines IL-6, IL-16, IL-18, and IL-36 in Patients with Multiple Sclerosis from the Western Region of Saudi Arabia: Associations with Disease Duration and Disability. [PDF]

Neurol Int
Alrahimi J, Mualla Y, Alhebshi A, Alnajashi HA, Zaher K.   +4 more
europepmc   +1 more source

Diagnostic potential of serum miR-197 and IL-18 levels in predicting bronchopulmonary dysplasia: a prospective cohort study. [PDF]

BMC Pediatr
Huang L, Fu X, Liu A, Cheng M, Xu X.
europepmc   +1 more source

Diagnostic Usefulness of SP-D, CCL2/MCP-1, and IL-18 in Assessing Respiratory Function and Risk of Pulmonary Fibrosis in COVID-19 Patients. [PDF]

Int J Mol Sci
Cylwik B, Gan K, Kazberuk M, Gruszewska E, Panasiuk A, Sienkiewicz M, Wojtkowska M, Chrostek L.   +7 more
europepmc   +1 more source

Association of IL-18 and CXCL10 Levels with Disease Severity in Vietnamese Patients with Dengue Infection. [PDF]

J Clin Med
Tran LH, Do CD, Nguyen PM, Nguyen BH, Nguyen LT, Hoang CX, Chu MD, Hoang SX.   +7 more
europepmc   +1 more source

Serologic IL-18 increase with B-cell IL-18R loss characterizes selective IgA deficiency. [PDF]

Front Immunol
Lemarquis AL, Sigurgrimsdottir H, Theodors FP, Karnsund I, Einarsdottir HK, Jorgensen G, Ekwall O, Jonsdottir I, Ludviksson BR.   +8 more
europepmc   +1 more source