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LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion. [PDF]
Front ImmunolDeloer S +7 more
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MHR: Basic science of reproductive medicine, 2001
To see whether the interleukin (IL)-18 system is operative in the endometrium, we examined the expression of IL-18, IL-18 receptor (IL-18R) and IL-18 binding protein (IL-18BP), the substance known to neutralize IL-18 activity, in this tissue. Reverse transcription-polymerase chain reaction analyses showed that IL-18, IL-18R and IL-18BP mRNA were ...
O, Yoshino +10 more
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To see whether the interleukin (IL)-18 system is operative in the endometrium, we examined the expression of IL-18, IL-18 receptor (IL-18R) and IL-18 binding protein (IL-18BP), the substance known to neutralize IL-18 activity, in this tissue. Reverse transcription-polymerase chain reaction analyses showed that IL-18, IL-18R and IL-18BP mRNA were ...
O, Yoshino +10 more
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Archives of Dermatological Research, 2001
Human interleukin-18 (IL-18) enhances IL-12-mediated IFN-gamma production by lymphocytes and Fas/perforin-mediated cytolysis by NK cells. IL-18 is synthesized as a 24 kDa proform, and the proform is processed in the cytoplasm into an 18 kDa mature form.
H, Koizumi +7 more
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Human interleukin-18 (IL-18) enhances IL-12-mediated IFN-gamma production by lymphocytes and Fas/perforin-mediated cytolysis by NK cells. IL-18 is synthesized as a 24 kDa proform, and the proform is processed in the cytoplasm into an 18 kDa mature form.
H, Koizumi +7 more
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Immunotherapeutic Applications of IL-18
Immunotherapy, 2012To become active and extracellularly released, IL-18 needs post-translational processing by the cytoplasmic enzyme caspase-1, which has high sequence homology with apoptotic cell death-associated enzymes in Caenorhabditis elegans. Furthermore, the receptor for IL-18 shares the signal transduction pathway with the Toll-like receptor, which highly ...
Hiroko, Tsutsui, Kenji, Nakanishi
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Expression of IL-18 in psoriasis
Archives of Dermatological Research, 2001Interleukin-18 (IL-18) is a novel cytokine that plays an important role in the T-helper 1 (Th1) response, primarily via its ability to induce IFN-gamma production in T cells and NK cells. Human keratinocytes produce IL-18, as do monocytes and macrophages, which are the two major sources of this molecule.
Y, Ohta, Y, Hamada, K, Katsuoka
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Nihon rinsho. Japanese journal of clinical medicine, 1998
Interleukin-18 (IL-18) is a recently cloned cytokine, produced from activated macrophages, including Kupffer cells. IL-18 is originally called interferon-gamma inducing factor (IGIF), due to its action to induce IFN-gamma production from Th 1 cells and NK cells.
S, Kashiwamura, H, Okamura
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Interleukin-18 (IL-18) is a recently cloned cytokine, produced from activated macrophages, including Kupffer cells. IL-18 is originally called interferon-gamma inducing factor (IGIF), due to its action to induce IFN-gamma production from Th 1 cells and NK cells.
S, Kashiwamura, H, Okamura
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Autoimmunity Reviews, 2009
IL-18 belongs to the IL-1 family of cytokines and has recently regained interest in the context of inflammasome activation. The inflammasome dependent caspase 1 cleaves pro-IL-18 into the active form - similar to what is known for IL-1ss. Still, the action and importance of IL-18 are not completely understood.
Miriam, Wittmann +2 more
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IL-18 belongs to the IL-1 family of cytokines and has recently regained interest in the context of inflammasome activation. The inflammasome dependent caspase 1 cleaves pro-IL-18 into the active form - similar to what is known for IL-1ss. Still, the action and importance of IL-18 are not completely understood.
Miriam, Wittmann +2 more
openaire +2 more sources
IL-18 gene polymorphisms affect IL-18 production capability by monocytes
Biochemical and Biophysical Research Communications, 2006We previously demonstrated a significant association between IL-18 gene polymorphism 105A/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105A/C and IL-18--137G/C was determined by PCR analyses.
Junsuke, Arimitsu +13 more
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The Journal of Biochemistry, 2005
IL-18 is an important regulator in both innate and acquired immune responses. The aberrant expression of IL-18 is associated with severe inflammatory conditions, such as autoimmune diseases and allergies. Thus, human antibodies with inhibitory activity on IL-18 signaling may be useful for therapeutic applications. We report here the first establishment
Takayuki, Hamasaki +6 more
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IL-18 is an important regulator in both innate and acquired immune responses. The aberrant expression of IL-18 is associated with severe inflammatory conditions, such as autoimmune diseases and allergies. Thus, human antibodies with inhibitory activity on IL-18 signaling may be useful for therapeutic applications. We report here the first establishment
Takayuki, Hamasaki +6 more
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Cloning and characterization of rhesus IL-18 binding protein, a natural antagonist to IL-18
Cytokine, 2010IL-18 is a proinflammatory cytokine that is important for host defense, but is also involved in the pathogenesis of a number of disease processes, ranging from autoimmune disorders to atherosclerosis. IL-18 binding protein (IL-18BP) is a constitutively expressed glycoprotein that specifically neutralizes the effects of IL-18, resulting in decreased ...
Srikanth, Yellayi +8 more
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