Results 51 to 60 of about 1,073,186 (289)

Interleukin-18 in Inflammatory Kidney Disease

Frontiers in Medicine, 2021
Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1β. IL-18 promotes the production of interferon gamma (IFN-γ) and strongly induces a Th1 response.
Yasuaki Hirooka, Yuji Nozaki
doaj   +1 more source

De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18).

, 2004
Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish, Heal, Jonathan R, Keller, Michael, Miller, Andrew D, Raynes, John G   +4 more
core   +1 more source

Interleukin-12 p40 secretion by cutaneous CD11c(+) and F4/80(+) cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni [PDF]

, 2003
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson, S, Hogg, K G, Kumkate, S, Mountford, A P   +3 more
core   +2 more sources

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C, Freeman, Tom, Hasegawa, Hitoshi, Herbert, Mark, McMichael, Andrew J, Willinger, Tim   +5 more
core   +1 more source

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
core   +2 more sources

Normal Free Interleukin-18 (IL-18) Plasma Levels in Dengue Virus Infection and the Need To Measure Both Total IL-18 and IL-18 Binding Protein Levels [PDF]

Clinical and Vaccine Immunology, 2015
ABSTRACT Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 (IL-18) is a proinflammatory cytokine that is increased during dengue and known to induce gamma interferon (IFN-γ), which is crucial for dengue immune response ...
Michels, M., Mast, Q. de, Netea, M.G., Joosten, L.A.B., Dinarello, C.A., Rudiman, P.I., Sinarta, S., Wisaksana, R., Alisjahbana, B., Ven, A. van der   +9 more
openaire   +3 more sources

Identification of small molecule inhibitors of Interleukin-18

Scientific Reports, 2017
Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive immune defense but its aberrant activities are also associated with inflammatory diseases such ...
Brian Krumm, Xiangzhi Meng, Yan Xiang, Junpeng Deng   +3 more
doaj   +1 more source

Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein

Frontiers in Immunology, 2012
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition due to the association of an infectious agent with lymphocyte cytotoxicity defects, either of congenital genetic origin in children or presumably acquired in adults. In HLH patients,
Laura eChiossone, Laura eChiossone, Laura eChiossone, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Sandra eAudonnet, Bruno eChetaille, Lionel eChasson, Lionel eChasson, Lionel eChasson, Catherine eFarnarier, Yael eBerda-Haddad, Stefan eJordan, Ulrich eKoszinowski, Marc eDalod, Marc eDalod, Marc eDalod, Karin eMazodier, Daniela eNovick, Charles eDinarello, Eric eVivier, Eric eVivier, Eric eVivier, Eric eVivier, Gilles eKaplanski   +25 more
doaj   +1 more source

Immunologic Function and Molecular Insight of Recombinant Interleukin-18. [PDF]

PLoS ONE, 2016
In recent years, cytokine-mediated therapy has emerged as further advance alternative in cancer therapy. Interleukin-18 (IL-18) has exhibited interesting anti-cancer properties especially when combined with IL-12.
Jirakrit Saetang, Aekkachai Puseenam, Niran Roongsawang, Supayang Piyawan Voravuthikunchai, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +1 more source

Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit

Virology, 2007
Interleukin-18 (IL-18) plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18 binding proteins (IL-18BP) that neutralize IL-18 activity. Here, we examined whether IL-18BP neutralizes IL-18 activity by binding to the same region of IL-18 where IL-18 receptor (IL-18R) binds.
Meng, Xiangzhi, Leman, Michael, Xiang, Yan   +2 more
openaire   +2 more sources