Results 61 to 70 of about 1,073,186 (289)

IL-6 and IL-18 cytokine traps in COVID-19

Инфекция и иммунитет
Cytokines are mediators of immunity that regulate inflammation. Intensity of inflammatory process is strongly dependent on the cytokine type and duration of its effect.
A. A. Korotaeva, Elena V. Samoilova, D. A. Chepurnova, N. V. Pogosova, D. T. Kuchiev, F. N. Paleev   +5 more
doaj   +1 more source

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

Journal of Neuroinflammation, 2012
Background Alzheimer’s disease (AD) involves increased accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles as well as neuronal loss in various regions of the neocortex.
Sutinen Elina M, Pirttilä Tuula, Anderson George, Salminen Antero, Ojala Johanna O   +4 more
doaj   +1 more source

Systemic Inflammasome Biomarkers as Predictors of Diabetic Retinopathy Progression: Evidence from a Pilot Study

Future Pharmacology, 2023
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) protein 3 (NLRP3) inflammasome pathway is believed to mediate chronic inflammation in diabetic retinopathy (DR); however, its impact on the progression of DR remains to be elucidated.
Charisse Y.-J. Kuo, Ilva D. Rupenthal, Michael Booth, Rinki Murphy, Odunayo O. Mugisho   +4 more
doaj   +1 more source

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller, AD Ellington, AI Nesvizhskii, Alana Sterkel, Alex Stewart, Alexey Wolfson, Allison Weiss, Andrew B. Dalby, AS Levey, AS Levey, Ashley Bock, Ashley Forbes, AW Bell, B Schweitzer, BE Eaton, Bharat Gawande, Brian Hicke, Bridget Lollo, Britta Singer, Bruce E. Eaton, C Borrebaeck, C Tuerk, Cate Fowler, Chi Zhang, Christopher Bock, D Schneider, D Venturoli, D Zichi, D Zichi, Dan Nieuwlandt, Daniel I. Resnicow, Daniel Levine, Daniel Schneider, Deborah Ayers, Dennis Halladay, Dom Zichi, Dylan Flather, Edward N. Brody, EN Brody, ES Gragoudas, Evaldas Katilius, Fabrizio Gelain, Glenn Sanders, Gregory Husar, HK Binz, IC van Riemsdijk-van Overbeeke, J Ninio, J Ruckman, J Silberring, JD Vaught, JD Vaught, Jeff Carter, Jeffrey J. Walker, Jennifer Bertino, Jim Heil, JJ Hopfield, Joe Heilig, John Rohloff, Jonathan D. Vaught, K Chaudhary, L Gold, L Liotta, LA Gugliotti, LA Stevens, Larry Gold, Luke Kroiss, M Famulok, M Pascual, Magda Gunn, Malti Nikrad, Martin Stanton, Matt Otis, Meredith Goss, Michele Nelson, Mike Mehan, Mike Vrkljan, Mike Watrobka, Nancy Kim, Nebojsa Janjic, Ngan Le, P Mitchell, R Aebersold, R Craig, R Vanholder, Rachel M. Ostroff, RD Jenison, RF Service, RM Ostroff, Robert Mehler, S Fredriksson, S Pan, SA Doggrell, Sally K. Nelson, Sarah Sattin, Shashi Gupta, Sheela Waugh, Sheri K. Wilcox, Stephan Kraemer, Steve Pietrasiewicz, Steven K. Wolk, Susan Jennings, Suzanne Stratford, SV Giannelli, T Dewey, TA Addona, Tad H. Koch, Thale Jarvis, Thomas Parker, Tim Fitzwater, TL Nickolas, TM Tarasow, Tracy R. Keeney, Trudi Foreman, Urs Ochsner, Wes Lindsey, Wes Mayfield   +115 more
core   +8 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Signal Transduction and Targeted Therapy, 2023
Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling ...
Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu, Yanan Sun, Weitao Cao, Ting Wang, Tae-Hwi Schwantes-An, John S. Choy, Samisubbu Naidu, Ang Luo, Wenguang Yin, Stephen M. Black, Jian Wang, Pixin Ran, Ankit A. Desai, Haiyang Tang   +16 more
doaj   +1 more source

Optineurin functions for optimal immunity [PDF]

, 2018
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source