Results 171 to 180 of about 65,138,242 (275)

Antibody framework engineering enables augmented cytokine receptor signaling capacities of bispecific single domain antibody-based IL-21 mimetics. [PDF]

MAbs
Lipinski B, Unmuth L, Tran THH, Harwood J, Arras P, Becker S, Harwardt J, Guarnera E, Helming L, Zaynagetdinov R, Bertoldo D, Rajpal A, Elter D, Pekar L, Evers A, Zielonka S.   +15 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

IL-21 boosts T cell-therapy efficacy for solid tumors by enhancing mitochondrial Ca2+-mediated motility of effector CD8+ T cells. [PDF]

Cancer Immunol Res
Hoen Rauhut M, Abdullahi F, Walters J, Patel HN, Stich D, Marié IJ, Wen H, Levy DE, Jacot JG, Jacobelli J, Valenca-Pereira F, Rincon M.   +11 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

IL-Info 21

, 1980
IL-INFO 21 IL-Info / Institut für Leichte Flächentragwerke (-) IL-Info 1-18 (1969 [6.-8-]) ( - ) IL-Info 1 (1.1970 eng) (-) IL-Info 2 (2. 1971 eng) (-) IL-Info 3 (3. 1971 eng) (-) IL-Info 4 (4. 1971 eng) (-) IL-Info 5
Universität Stuttgart. Institut für Leichte Flächentragwerke
core  

IL-21 controls CD8 ⁺ T cell immunity and antibacterial defense in fish via STAT3 signaling. [PDF]

Zool Res
Cao Y, Rao W, Chen H, Li K, Zhu Y, Fang Z, Zheng Y, Geng M, Zhang J, Yang J, Wei X.   +10 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Reversing Dysfunction of CCR9⁺ Regulatory T Cells by Targeting the IL-21/IL-17 Axis Improves Type 1 Diabetes. [PDF]

Diabetes Metab Syndr Obes
Xia Y, He Q, Yao Y, Yang L, Zhan S, Mao S.   +5 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Modulation of pulmonary IL-21 expression during latent TB and M. tuberculosis/SIV coinfection. [PDF]

JCI Insight
Shivanna V, Escalona RD, Chuba C, Singh SP, Moustafa AA, Brown JQ, Xiao C, Kim S, Dick EJ, Mehra S, Paiardini M, Sharan R.   +11 more
europepmc   +1 more source