Results 171 to 180 of about 6,541,017 (281)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dock2 Protects Colitis by Facilitating Akkermansia Colonization via Suppressing IL-22-Reg3 Activity. [PDF]

Inflammation
Lu M, Xu S, Tan Y, Deng J, Feng B, Qiu D, Wang X, Sun H, Ji K, Zhu B, Hu S, Wu X, Chen M, Iwakura Y, Wang X, Feng R, Qi Y, Tang C.   +17 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis. [PDF]

J Exp Med
Fachi JL, Trsan T, Sécca C, de Oliveira S, Rodovalho VR, Rodrigues PF, Beatty WL, Sudan R, Wu S, Bhattarai B, Panda SK, Cella M, Gilfillan S, Colonna M.   +13 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Relationship of the Specific Inflammatory Cytokines KLK5, IL-8, and IL-22 with Demodex Density and Risk Factors in Rosacea [PDF]

Jingang Xu,1,* Yao Zhang,1,* Chao Ci,2 Xiaohong Lu,2 Xing Hu,3 Jinhong Zhao,1 Yuanyuan Li1 1Department of Medical Parasitology, Wannan Medical College, Wuhu, Anhui, 241002, People’s Republic of China; 2Department of Dermatology, Yijishan ...
Li Y, Lu X, Zhang Y, Hu X, Ci C, Zhao J, Xu J   +6 more
core   +1 more source

Deciphering the Role of Innate Lymphoid Cells Group 3 in the Gut Microenvironment: A Narrative Review of Their Novel Contributions to Autoimmune Disease Pathogenesis

Journal of Inflammation Research
Hongli Wang,1,2 Tengyue Wang,1,2 Zhixing He,1,2 Chengping Wen,1,2 Lin Huang,1,2 Mingzhu Wang1,2 1Research Institute of Chinese Medical Clinical Foundation and Immunology, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou ...
Wang H, Wang T, He Z, Wen C, Huang L, Wang M   +5 more
doaj  

An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen. [PDF]

PLoS Pathog
Coleman BM, Cook ME, Khan MR, Vogel AK, Wells AJ, Miao J, Vyas SP, Taylor TC, Aggor FEY, Ponde NO, Dey I, Zou H, Jašarević E, Peters BM, Gaffen SL.   +14 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source