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Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling
Science Signaling, 2016Two soluble binding proteins that differ in inhibitory ability and abundance fine-tune signaling by the cytokine interleukin-22.
Chrissie, Lim, MeeAe, Hong, Ram, Savan
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Effects of IL-22 on cardiovascular diseases
International Immunopharmacology, 2020Interleukin-22 (IL-22), which belongs to the IL-10 family, is an alpha helix cytokine specifically produced by many lymphocytes, such as Th1, Th17, Th22, ILCs, CD4+ and CD8+ T cells. In recent years, more and more studies have demonstrated that IL-22 has an interesting relationship with various cardiovascular diseases, including myocarditis, myocardial
Yang, Che, Zhaoliang, Su, Lin, Xia
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IL-22 Signaling in the Tumor Microenvironment
2021Interleukin (IL)-22 belongs to the IL-10 cytokine family which performs biological functions by binding to heterodimer receptors comprising a type 1 receptor chain (R1) and a type 2 receptor chain (R2). IL-22 is mainly derived from CD4+ helper T cells, CD8+ cytotoxic T cells, innate lymphocytes, and natural killer T cells.
Runqiu, Jiang, Beicheng, Sun
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IL-22, cell regeneration and autoimmunity
Cytokine, 2015IL-22 as a cytokine is described with opposing pro-inflammatory and anti-inflammatory functions. Cell regeneration, tissue remodelling and balance between commensal bacteria in the gut and host immune system are considered as anti-inflammatory features of IL-22, whereas production of IL-22 from Th17 cells links this cytokine to pro-inflammatory ...
Enayat Nikoopour +2 more
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Medical Oncology
Interleukin-22, discovered in the year of 2000, is a pleiotropic Th17 cytokine from the IL-10 family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and predominantly activates STAT3. This pathway leads to the transcription of several different types of genes, giving IL-22 context-specific functions ranging from inducing
Zachary E, Hunzeker +8 more
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Interleukin-22, discovered in the year of 2000, is a pleiotropic Th17 cytokine from the IL-10 family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and predominantly activates STAT3. This pathway leads to the transcription of several different types of genes, giving IL-22 context-specific functions ranging from inducing
Zachary E, Hunzeker +8 more
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The enigmatic role of IL-22 in asthma
Expert Review of Respiratory Medicine, 2016Asthma is a complex, heterogeneous disorder with increasing prevalence. It is now recognized that several asthma phenotypes exist, including type 2-high and type 2-low (or non-type 2) subsets. As current research strives to identify subgroups of asthmatics that share disease pathobiology to establish endotypes, efforts to clarify the underlying ...
Michelle L, Manni, John F, Alcorn
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MicroRNAs: New regulators of IL-22
Cellular Immunology, 2016Interleukin-22 (IL-22) is a cytokine that belongs to the IL-10 family of interleukins. It can be produced by T helper 22 (Th22) cells, T helper 1 (Th1) cells, T helper 17 (Th17) cells, natural killer 22 (NK22) cells, natural killer T (NKT) cells, innate lymphoid cells (ILCs), and γδ T cells.
Zhou, Lu +3 more
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IL-22: Scavenging beyond the barrier
Science Immunology, 2017IL-22–induced hemopexin promotes nutritional immunity by scavenging iron from Citrobacter rodentium during systemic infection. See the related Research Article by Sakamoto et al .
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Science, 2012
Damage to the thymus caused by infection or radiation is reversed by a cytokine.
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Damage to the thymus caused by infection or radiation is reversed by a cytokine.
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Science, 2020
Innate Lymphoid Cells Secretion of the cytokine interleukin-22 (IL-22) by innate lymphoid cells and intestinal T cells in the gut promotes epithelial integrity and provides protection against intestinal pathogens. Bauche et al. investigated which cytokines and signal transducer and activator of transcription (STAT) proteins activate IL-22 production by
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Innate Lymphoid Cells Secretion of the cytokine interleukin-22 (IL-22) by innate lymphoid cells and intestinal T cells in the gut promotes epithelial integrity and provides protection against intestinal pathogens. Bauche et al. investigated which cytokines and signal transducer and activator of transcription (STAT) proteins activate IL-22 production by
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