Results 261 to 270 of about 6,541,017 (281)

IL-22 Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Epithelial Cell Apoptosis Associated with STAT3 Signalling. [PDF]

J Inflamm Res
Zhu C, Chen J, Yan Z, Wang F, Sun Z, Liu Z, Li Y, Chen X, Bao Z, Li Q, Chen Z.   +10 more
europepmc   +1 more source

Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection. [PDF]

Cell Rep
Mears KS, Denny JE, Maslanka JR, Mdluli NV, Hulit EN, Matsuda R, Furth EE, Buffie CG, Abt MC.   +8 more
europepmc   +1 more source

Carotid baroreceptor stimulation attenuates obesity-related hypertension through sympathetic-driven IL- 22 restoration of intestinal homeostasis. [PDF]

Eur J Med Res
Shu L, Xiao L, Hu B, Yu Q, Dai D, Chen J, Wang J, Xi Z, Zhang J, Bao M.   +9 more
europepmc   +1 more source

IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression <i>via</i> ERK1/2 activation.

World J Gastrointest Oncol
Zhou J, Chen JR, Li JM, Han SQ, Deng XY, Li ZM, Tong W, Wang C, Bai Y, Zhang YM.   +9 more
europepmc   +1 more source

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Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling

Science Signaling, 2016
Two soluble binding proteins that differ in inhibitory ability and abundance fine-tune signaling by the cytokine interleukin-22.
Chrissie, Lim, MeeAe, Hong, Ram, Savan
openaire   +3 more sources

Effects of IL-22 on cardiovascular diseases

International Immunopharmacology, 2020
Interleukin-22 (IL-22), which belongs to the IL-10 family, is an alpha helix cytokine specifically produced by many lymphocytes, such as Th1, Th17, Th22, ILCs, CD4+ and CD8+ T cells. In recent years, more and more studies have demonstrated that IL-22 has an interesting relationship with various cardiovascular diseases, including myocarditis, myocardial
Yang, Che, Zhaoliang, Su, Lin, Xia
openaire   +2 more sources

IL-22 Signaling in the Tumor Microenvironment

2021
Interleukin (IL)-22 belongs to the IL-10 cytokine family which performs biological functions by binding to heterodimer receptors comprising a type 1 receptor chain (R1) and a type 2 receptor chain (R2). IL-22 is mainly derived from CD4+ helper T cells, CD8+ cytotoxic T cells, innate lymphocytes, and natural killer T cells.
Runqiu, Jiang, Beicheng, Sun
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The enigmatic role of IL-22 in asthma

Expert Review of Respiratory Medicine, 2016
Asthma is a complex, heterogeneous disorder with increasing prevalence. It is now recognized that several asthma phenotypes exist, including type 2-high and type 2-low (or non-type 2) subsets. As current research strives to identify subgroups of asthmatics that share disease pathobiology to establish endotypes, efforts to clarify the underlying ...
Michelle L, Manni, John F, Alcorn
openaire   +2 more sources

The role of IL-22 in cancer

Medical Oncology
Interleukin-22, discovered in the year of 2000, is a pleiotropic Th17 cytokine from the IL-10 family of cytokines. IL-22 signals through the type 2 cytokine receptor complex IL-22R and predominantly activates STAT3. This pathway leads to the transcription of several different types of genes, giving IL-22 context-specific functions ranging from inducing
Zachary E, Hunzeker, Lei, Zhao, Austin M, Kim, Jacob M, Parker, Ziwen, Zhu, Huaping, Xiao, Qian, Bai, Mark R, Wakefield, Yujiang, Fang   +8 more
openaire   +2 more sources

MicroRNAs: New regulators of IL-22

Cellular Immunology, 2016
Interleukin-22 (IL-22) is a cytokine that belongs to the IL-10 family of interleukins. It can be produced by T helper 22 (Th22) cells, T helper 1 (Th1) cells, T helper 17 (Th17) cells, natural killer 22 (NK22) cells, natural killer T (NKT) cells, innate lymphoid cells (ILCs), and γδ T cells.
Zhou, Lu, Ronghua, Liu, Enyu, Huang, Yiwei, Chu   +3 more
openaire   +2 more sources