Results 91 to 100 of about 1,415,739 (335)
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. [PDF]
, 2017 The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly ...
Brown Swigart, Lamorna +7 more
core +1 more source
TAMI-23. ANTIBODY COCKTAIL IMMUNOTHERAPY FOR GLIOBLASTOMA BY DUAL TARGETING OF IL-6 AND CD40 [PDF]
, 2021 Fan Yang, Steven Brem, Yi Fan
openalex +1 more source
Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report
Pediatric Blood &Cancer, EarlyView.ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan +6 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee +9 more
wiley +1 more source
Association between Interleukin-23 Receptor R381Q Gene. [PDF]
, 2015 The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the
Ganjalikhani Hakemi, Mazdak. +5 more
core +2 more sources
A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients
Ibn Al-Haitham Journal for Pure and Applied SciencesPsoriasis is defined as a series of events that begins in its initial stage with dermatitis and then progresses to more widespread inflammation and increased oxidative stress.
Samara Amar Sabri, Shaima R. Ibraheem
doaj +1 more source
Salivary Levels of Interleukin-23 in Iranian Patients with Systemic Sclerosis [PDF]
Journal of Kerman University of Medical SciencesBackground: Systemic sclerosis (SSc) is a rare chronic inflammatory disorder characterized by diffuse fibrosis and vascular abnormalities in the skin and internal organs.
Ali Tadayon +4 more
doaj +1 more source
Nociceptive Sensory Neurons Drive Interleukin-23 Mediated Psoriasiform Skin Inflammation [PDF]
, 2015 The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbors specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17 ...
Alvarez, David +7 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song +15 more
wiley +1 more source
Frontiers in ImmunologyBackgroundPsoriatic arthritis (PsA) is a chronic inflammatory disease that impacts both the skin and joints. Currently, interleukin (IL)-17, IL-12/23, and IL-23 inhibitors have become integral components of PsA treatment regimens.
Shan Gao +3 more
doaj +1 more source