Results 101 to 110 of about 8,411,708 (236)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
La disciplina dei licenziamenti dopo il d. lgs n. 23/2015
, 2016 La disciplina dei licenziamenti dopo il d. lgs n.
F. Santoni
core
, 1982 IL-INFO 23 IL-Info / Institut für Leichte Flächentragwerke (-) IL-Info 1-18 (1969 [6.-8-]) ( - ) IL-Info 1 (1.1970 eng) (-) IL-Info 2 (2. 1971 eng) (-) IL-Info 3 (3. 1971 eng) (-) IL-Info 4 (4. 1971 eng) (-) IL-Info 5
Universität Stuttgart. Institut für Leichte Flächentragwerke
core +4 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy [PDF]
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease.
Ritchlin, Christopher T. +22 more
core +1 more source
IL-23 induces pRLC-S20 through JAK2 and ROCK dependent mechanisms in Tγδ17 cells.
, 2020 (a) IL-7-expanded Tγδ17 cells were stimulated with IL-23 in presence or absence of the indicated JAK2 inhibitors or left unstimulated (uns.) for 6 h before assessing pSTAT3-Y705 and pRLC-S20 by flow cytometry.
Candelas Álvarez-Salamero (8611707) +6 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source