Results 111 to 120 of about 1,375,213 (331)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Spotlight on risankizumab and its potential in the treatment of plaque psoriasis: evidence to date

Psoriasis: Targets and Therapy, 2018
Álvaro Machado,1 Tiago Torres1,2 1Department of Dermatology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal Abstract: Psoriasis is
Machado Á, Torres T
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

Journal of Translational Autoimmunity
In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases.
Xiaoyu Cui, Wu Liu, Hanxue Jiang, Qihan Zhao, Yuehong Hu, Xinyue Tang, Xianli Liu, Haoran Dai, Hongliang Rui, Baoli Liu   +9 more
doaj   +1 more source

Risankizumab for the Treatment of the Patients with Moderate to Severe Plaque Psoriasis During a 24-Week Period: Real-Life Experience

Clinical, Cosmetic and Investigational Dermatology, 2023
Melis Gönülal,1 Didem Didar Balcı,1 Serap Öztürkcan2 1Department of Dermatology, University of Health Sciences, Izmir Tepecik Training and Research Hospital, İzmir, Turkey; 2Department of Dermatology, Manisa Celal Bayar University Hafsa ...
Gönülal M, Balcı DD, Öztürkcan S
doaj  

Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection [PDF]

, 2011
Jessica L. Werner, Melissa A. Gessner, Lauren Lilly, Michael Nelson, Allison E. Metz, Dawn Horn, Chad W. Dunaway, Jessy S. Deshane, David Chaplin, Casey T. Weaver, Gordon D. Brown, Chad Steele   +11 more
openalex   +1 more source

Bone marrow dendritic cells deficient for CD40 and IL-23p19 are tolerogenic in vitro [PDF]

, 2020
Objective(s): In addition to pro-inflammatory role, dendritic cells (DCs) can also be anti-inflammatory when they acquire tolerogenic phenotype. In this study we tested the role of CD40 and IL-23p19 in antigen presenting function of bone marrow-derived ...
Ciric, Bogoljub, Kalantari, Tahereh, Kamali-Sarvestani, Eskandar, Rostami, Abdolmohamad   +3 more
core   +1 more source

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis. [PDF]

, 2016
The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy.
Albers, Michael, Banie, Homayon, Budelsky, Alison L., Castro, Glenda, De Leon-Tabaldo, Aimee, Fourie, Anne M., Fung-Leung, Wai-Ping, Leonard, Kristi, Luna-Roman, Rosa, Rozenkrants, Natasha, Sablad, Marciano, Santamaria Babí, Luis F., Schlueter, Thomas, Soroosh, Pejman, Xue, Xiaohua, Yu, Jingxue   +15 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets

Frontiers in Immunology, 2019
TYK2 is a JAK family member that functions downstream of multiple cytokine receptors. Genome wide association studies have linked a SNP (rs34536443) within TYK2 encoding a Proline to Alanine substitution at amino acid 1104, to protection from multiple ...
Jacquelyn A. Gorman, Christian Hundhausen, Mackenzie Kinsman, Tanvi Arkatkar, Eric J. Allenspach, Eric J. Allenspach, Courtnee Clough, Samuel E. West, Kerri Thomas, Kerri Thomas, Ahmet Eken, Socheath Khim, Malika Hale, Malika Hale, Mohamed Oukka, Mohamed Oukka, Mohamed Oukka, Shaun W. Jackson, Shaun W. Jackson, Karen Cerosaletti, Jane H. Buckner, David J. Rawlings, David J. Rawlings, David J. Rawlings   +23 more
doaj   +1 more source