Results 141 to 150 of about 1,415,739 (335)

A Comparative Study on Serum Levels of “Thymic Stromal Lymphopoietin” Between Patients with Psoriasis Vulgaris and Healthy Individuals: A Case-Control Study

Indian Dermatology Online Journal
Background: Thymic stromal lymphopoietin (TSLP) is a cytokine initially implicated to be associated with allergic disorders inducing Th2 response. Emerging studies have shown that TSLP is also involved in autoimmune diseases.
Siri Sri Kollabathula, Konakanchi Venkatachalam, Kethireddi Susmitha Divya, Patnala Guruprasad, Pallapati Anila Sunandini Nayar   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The mode of action of IL-23 in experimental inflammatory arthritic pain and disease

Arthritis Research & Therapy
Objectives We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease.
Kevin M.-C. Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey, Martha Zeeman, Anne M. Fourie, John A. Hamilton   +6 more
doaj   +1 more source

Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection [PDF]

, 2011
Jessica L. Werner, Melissa A. Gessner, Lauren Lilly, Michael Nelson, Allison E. Metz, Dawn Horn, Chad W. Dunaway, Jessy S. Deshane, David Chaplin, Casey T. Weaver, Gordon D. Brown, Chad Steele   +11 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis

Научно-практическая ревматология
The aim of the study was to determine the clinical and diagnostic value of interleukin (IL) 17A, IL-17F and IL-23 in rheumatoid arthritis (RA) patients in the advanced stage of the disease.Materials and methods.
Natalia A. Lapkina, Andrey A. Baranov, Olga P. Rechkina, Natalia E. Abaytova, Svetlana S. Zolotavkina, Alexander S. Artyuhov, Evgeny L. Nasonov   +6 more
doaj   +1 more source

The role of IL-12/23 in T cell–related chronic inflammation: implications of immunodeficiency and therapeutic blockade [PDF]

, 2017
Anna Schurich, Charles Raine, Vanessa Morris, Coziana Ciurtin   +3 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Review of Ankylosing Spondylitis [PDF]

, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

Tolerability and comparative effectiveness of TNF, IL-17 and IL-23(p19) inhibitors in psoriatic arthritis: a target trial emulation study [PDF]

, 2023
Zara R. Stisen, Sabrina Mai Nielsen, Marie Skougaard, Mette Mogensen, Tanja Schjødt Jørgensen, Lene Dreyer, Maarten de Wit, Robin Christensen, Lars Erik Kristensen   +8 more
openalex   +1 more source