Results 241 to 250 of about 63,242,370 (271)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

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Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

Journal of Allergy and Clinical Immunology, 2011
IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses.To address the hypothesis that allergen provocation increases expression of IL-25 and its receptor IL-25R in the asthmatic bronchial mucosa and skin dermis of atopic subjects.Sequential single and double immunostaining was used to evaluate the numbers and ...
Corrigan, Chris J., Wang, Wei, Meng, Qiu, Fang, Cailong, Eid, Ghada, Caballero, M. Rosario, Lv, Ze, An, Yunqing, Wang, Yui-Hsi, Liu, Yong-Jun, Kay, A. Barry, Lee, Tak H., Sun, Ying   +12 more
openaire   +3 more sources

IL-25, another promoter of allergy

2009
Although there have been significant insights into the mechanism underlying the initiation of type 1 immune response, how type 2-mediated pathology especially allergic diseases is developed remains unclear. Cytokine environment is important in shaping and initiating Th2 responses. IL-25, also called IL-17E, belongs to the IL-17 family but, unlike other
Pornpimon Angkasekwinai, Chen Dong
openaire   +1 more source

Topical Corticosteroids Decrease IL-25 Expression by Immunohistochemistry

ORL, 2019
<b><i>Background:</i></b> Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS)
Hany Samir, Moustafa, Mohamed, Qotb, Mohammed Ahmed, Hussein, Ahmed, Eid, Essam Ezzat, Ayad, Tamer, Fawzy   +5 more
openaire   +2 more sources

IL-25 as a Potential Therapeutic Target in Allergic Asthma

Immunotherapy, 2015
Allergic asthma is a prevalent disease characterized by intermittent airway hyperresponsiveness resulting in airway narrowing, debilitating wheezing and shortness of breath that in severe cases can prove fatal. Notably, the number of sufferers, especially among children, has increased dramatically over recent decades and the WHO estimates that 235 ...
Martin D, Knolle, Batika M, Rana, Andrew N J, McKenzie   +2 more
openaire   +2 more sources

The Role of IL-25 and IL-35 in Amoebiasis

Indian Journal of Forensic Medicine & Toxicology, 2021
Bacground: Amoebiasis is a protazon infection of the human intestine spread through the world the mostprevelant form of the disease is amebic dysenterywhich characterizes acute diarrhoea with observable bloodand mucus in stools.Aims: This article aimed to detects the role of IL-25 and IL-35 in the immune response against amebicdysentery.Methods: This ...
openaire   +1 more source