Results 241 to 250 of about 9,708,765 (268)

IL-25 and IL-25 Receptor Expression on Eosinophils from Subjects with Allergic Asthma

International Archives of Allergy and Immunology, 2013
<b><i>Background:</i></b> Allergic asthma is an inflammatory airway disease in which Th2 cytokines play an important role. Epithelial-derived interleukin (IL)-25 has been suggested to be important in the maintenance of Th2-type responses.
Tang, Wei, Smith, Steven G, Beaudin, Sue, Dua, Benny, Howie, Karen, Gauvreau, Gail, O'Byrne, Paul M   +6 more
openaire   +4 more sources

IL-25 (IL-17E) in epithelial immunology and pathophysiology

Journal of Allergy and Clinical Immunology, 2021
IL-25, also known as IL-17E, is a unique cytokine of the IL-17 family. Indeed, IL-25 exclusively was shown to strongly induce expression of the cytokines associated with type 2 immunity. Although produced by several types of immune cells, such as T cells, dendritic cells, or group 2 innate lymphoid cells, a vast amount of IL-25 derives from epithelial ...
Borowczyk, Julia, Shutova, Maria, Brembilla, Nicolo, Boehncke, Wolf-Henning   +3 more
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Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

Journal of Allergy and Clinical Immunology, 2011
IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses.To address the hypothesis that allergen provocation increases expression of IL-25 and its receptor IL-25R in the asthmatic bronchial mucosa and skin dermis of atopic subjects.Sequential single and double immunostaining was used to evaluate the numbers and ...
Corrigan, Chris J., Wang, Wei, Meng, Qiu, Fang, Cailong, Eid, Ghada, Caballero, M. Rosario, Lv, Ze, An, Yunqing, Wang, Yui-Hsi, Liu, Yong-Jun, Kay, A. Barry, Lee, Tak H., Sun, Ying   +12 more
openaire   +3 more sources

IL-25, another promoter of allergy

2009
Although there have been significant insights into the mechanism underlying the initiation of type 1 immune response, how type 2-mediated pathology especially allergic diseases is developed remains unclear. Cytokine environment is important in shaping and initiating Th2 responses. IL-25, also called IL-17E, belongs to the IL-17 family but, unlike other
Pornpimon Angkasekwinai, Chen Dong
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Topical Corticosteroids Decrease IL-25 Expression by Immunohistochemistry

ORL, 2019
<b><i>Background:</i></b> Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS)
Hany Samir, Moustafa, Mohamed, Qotb, Mohammed Ahmed, Hussein, Ahmed, Eid, Essam Ezzat, Ayad, Tamer, Fawzy   +5 more
openaire   +2 more sources

IL-25 as a Potential Therapeutic Target in Allergic Asthma

Immunotherapy, 2015
Allergic asthma is a prevalent disease characterized by intermittent airway hyperresponsiveness resulting in airway narrowing, debilitating wheezing and shortness of breath that in severe cases can prove fatal. Notably, the number of sufferers, especially among children, has increased dramatically over recent decades and the WHO estimates that 235 ...
Martin D, Knolle, Batika M, Rana, Andrew N J, McKenzie   +2 more
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The Role of IL-25 and IL-35 in Amoebiasis

Indian Journal of Forensic Medicine & Toxicology, 2021
Bacground: Amoebiasis is a protazon infection of the human intestine spread through the world the mostprevelant form of the disease is amebic dysenterywhich characterizes acute diarrhoea with observable bloodand mucus in stools.Aims: This article aimed to detects the role of IL-25 and IL-35 in the immune response against amebicdysentery.Methods: This ...
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IL‐25 protects against high‐fat diet‐induced hepatic steatosis in mice by inducing IL‐25 and M2a macrophage production

Immunology & Cell Biology, 2018
AbstractInterleukin (IL)‐25 is a cytokine that has previously been shown to have a protective role against nonalcoholic fatty liver disease (NAFLD), which is associated with the induction of M2 macrophage differentiation. However, the direct relationships between IL‐25 expression regulation, M2 induction and NAFLD remain unknown.
Xue-Lian, Zheng, Jian-Ping, Wu, Yue, Gong, Jun-Bo, Hong, Hai-Ying, Xiao, Jia-Wei, Zhong, Bo, Xie, Bi-Min, Li, Gui-Hai, Guo, Xuan, Zhu, An-Jiang, Wang   +10 more
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Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

Journal of Allergy and Clinical Immunology, 2007
IL-25 (IL-17E), a member of the IL-17 family of immunoregulatory cytokines, has been implicated in the regulation of type 2 immunity. Its roles in antigen-driven airway inflammation and airway hyperresponsiveness (AHR) remain to be fully established.We sought to determine whether a neutralizing antibody against IL-25 represents a novel therapeutic for ...
Sarah J, Ballantyne, Jillian L, Barlow, Helen E, Jolin, Puneeta, Nath, Alison S, Williams, Kian Fan, Chung, Graham, Sturton, See Heng, Wong, Andrew N J, McKenzie   +8 more
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IL‐25: A key requirement for the regulation of type‐2 immunity

BioFactors, 2009
AbstractIt has been well‐established that type‐2 immunity, characterized by eosinophilia, goblet cell hyperplasia, mucus production, and B cell class switching to IgE, is highly dependent on the production of the type‐2 cytokines, interleukin (IL)‐4, IL‐5, IL‐9, and IL‐13, by T helper 2 (Th2) cells.
Jillian L, Barlow, Andrew N J, McKenzie
openaire   +2 more sources