Results 121 to 130 of about 1,155,232 (268)

Cost Estimate Modeling of Transportation Management Plans for Highway Projects, Research Report 11-24 [PDF]

open access: yes, 2012
Highway rehabilitation and reconstruction projects frequently cause road congestion and increase safety concerns while limiting access for road users.
Ellis, Ralph D.   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

open access: yesMediators of Inflammation, 2014
Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of ...
Anna Bonanno   +7 more
doaj   +1 more source

Campagnes Chalci, Chalci 83-01 (du 11 au 19-01-83) et Chalci 83-02 (du 10 au 18-03-83): resultats des chalutages [PDF]

open access: yes, 1983
This publication gives the results of bottom trawlings made during the cruises Chalci 83.01 and Chalci 83.02 by the oceanographic research vessel "André Nizery", on the ivorian continental shelf.
Lhomme, F.
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

L'Offerta ricettiva e la domanda turistica negli ambiti di paesaggio costieri del Nord Sardegna [PDF]

open access: yes, 2009
Il Piano paesaggistico regionale (sinteticamente denominato PPR) è stato predisposto e approvato dalla Regione Autonoma della Sardegna con decreto del presidente 7 settembre 2006, n. 82, pubblicato nel "BURAS", n. 30 dell'8 settembre 2006.
Donato, Carlo, Mele, Gesuina
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

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