Results 121 to 130 of about 1,179,733 (270)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

State space collapse and diffusion approximation for a network operating under a fair bandwidth sharing policy

, 2012
We consider a connection-level model of Internet congestion control, introduced by Massouli\'{e} and Roberts [Telecommunication Systems 15 (2000) 185--201], that represents the randomly varying number of flows present in a network.
Kang, W. N., Kelly, F. P., Lee, N. H., Williams, R. J.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cost Estimate Modeling of Transportation Management Plans for Highway Projects, Research Report 11-24 [PDF]

, 2012
Highway rehabilitation and reconstruction projects frequently cause road congestion and increase safety concerns while limiting access for road users.
Ellis, Ralph D., Lee, Eul-Bum, Park, Taeho, Pyeon, Jae-Ho   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

L'Offerta ricettiva e la domanda turistica negli ambiti di paesaggio costieri del Nord Sardegna [PDF]

, 2009
Il Piano paesaggistico regionale (sinteticamente denominato PPR) è stato predisposto e approvato dalla Regione Autonoma della Sardegna con decreto del presidente 7 settembre 2006, n. 82, pubblicato nel "BURAS", n. 30 dell'8 settembre 2006.
Donato, Carlo, Mele, Gesuina
core  

25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

Mediators of Inflammation, 2014
Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of ...
Anna Bonanno, Sebastiano Gangemi, Stefania La Grutta, Velia Malizia, Loredana Riccobono, Paolo Colombo, Fabio Cibella, Mirella Profita   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Spartan Daily, March 6, 1980 [PDF]

, 1980
Volume 74, Issue 25https://scholarworks.sjsu.edu/spartandaily/6592/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source