TNT equivalency of M10 propellant [PDF]
Peak, side-on blast overpressure and scaled, positive impulse have been measured for M10 single-perforated propellant, web size 0.018 inches, using configurations that simulate the handling of bulk material during processing and shipment.
Mcintyre, F. L., Price, P.
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
New insights on IL‑36 in intestinal inflammation and colorectal cancer (Review). [PDF]
Exp Ther Med, 2023 Li M, Jiang W, Wang Z, Lu Y, Zhang J.
europepmc +1 more source
Optimum design of composite laminates with thermal effects [PDF]
An analytical approach to determine an optimum laminate for a variety of thermal and mechanical loading combinations is presented. The analysis is performed for a linear elastic material under static mechanical and uniform thermal loadings.
Herakovich, C. T., Markham, L. R.
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2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells. [PDF]
, 2019 The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22.
Adamopoulos, Iannis E +12 more
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis. [PDF]
Br J Cancer, 2023 Baker KJ, Brint E, Houston A.
europepmc +1 more source
A fundamental approach to adhesion: Synthesis, surface analysis, thermodynamics and mechanics [PDF]
The effects of composites as adherends was studied. Several other variables were studied by fractography: aluminum powder adhesive filler, fiber glass cloth scrim or adhesive carrier, new adhesives PPQ-413 and LARC-13, and strength-test temperature. When
Dwight, D. W., Wightman, J. P.
core +2 more sources