Results 161 to 170 of about 6,730,703 (222)

MES SV40 Cells Are Sensitive to Lipopolysaccharide, Peptidoglycan, and Poly I:C Expressing IL-36 Cytokines. [PDF]

Int J Mol Sci, 2022
Pelcastre-Rodriguez CG, Vazquez-Sanchez EA, Murrieta-Coxca JM, Rodríguez-Martínez S, Cancino-Diaz JC, Cancino-Diaz ME.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Serum Levels of the Proinflammatory Cytokines IL-6, IL-16, IL-18, and IL-36 in Patients with Multiple Sclerosis from the Western Region of Saudi Arabia: Associations with Disease Duration and Disability. [PDF]

Neurol Int
Alrahimi J, Mualla Y, Alhebshi A, Alnajashi HA, Zaher K.   +4 more
europepmc   +1 more source

IL-36 cytokines imprint a colitogenic phenotype on CD4⁺ T helper cells. [PDF]

Mucosal Immunol, 2022
Leon G, Hernandez Santana YE, Irwin N, Giannoudaki E, O'Neill S, Csizmadia I, Gogarty M, Lee TJ, Ruane D, Long A, Fallon PG, Hussey S, Walsh PT.   +12 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The IL-36 Cytokine Rheostat: Hierarchical Regulation of Epithelial–Immune Crosstalk and Precision Therapy in Psoriatic and Related Dermatoses

Clinical, Cosmetic and Investigational Dermatology
Ze-Yun Qiao,1 Jing-Hua Liu,1 Na-Na Luo,2 Lei Tang,1 Wen-Yi Ma,1 Zi-Lin Cheng,1 Ping-Sheng Hao1,2 1Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2Department of ...
Qiao ZY, Liu JH, Luo NN, Tang L, Ma WY, Cheng ZL, Hao PS   +6 more
doaj  

Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma. [PDF]

Genes Dis
An J, Liao Q, Yu Z, Du Z, Du J, Xiao Q, Jiang T, Huang C, Xie K.   +8 more
europepmc   +1 more source

IL-36 in chronic inflammation and fibrosis - bridging the gap? [PDF]

J Clin Invest, 2021
Elias M, Zhao S, Le HT, Wang J, Neurath MF, Neufert C, Fiocchi C, Rieder F.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source