Results 161 to 170 of about 1,058,192 (273)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Targeting IL-36 in Inflammatory Skin Diseases

Targeting IL-36 in Inflammatory Skin Diseases
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36 cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists (IL-36 receptor antagonist [IL36Ra] and IL-38). These work in innate and acquired immunity and are known to contribute to host defense and to the pathogenesis of autoinflammatory
openaire  

Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis. [PDF]

Allergy Asthma Clin Immunol, 2023
Gu J, Qin G, Jiang L, Xu W, Wang Y, Liao J, Pan H, Liang Z.   +7 more
europepmc   +1 more source

Social Preferences - Literature Survey [PDF]

This paper surveys the theories of social preferences. Social preferences are based on that people not only care about their own well-being, but they have a certain concern with payoffs and/or actions of others. We classify two approaches: distributional
Kovarik, Jaromir
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis. [PDF]

JCI Insight
Seki T, Kim JD, Yahara Y, Uchida H, Yaku K, Karim M, Makino T, Shimizu T, Nakagawa T.   +8 more
europepmc   +1 more source

IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD. [PDF]

JCI Insight, 2022
Baker JR, Fenwick PS, Koss CK, Owles HB, Elkin SL, Fine J, Thomas M, El Kasmi KC, Barnes PJ, Donnelly LE.   +9 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IL-36 mediates immune activation in Sjögren's disease and may represent a novel biomarker of disease. [PDF]

J Leukoc Biol
Alhaddad B, Wrynn T, Kiripolsky J, Kasperek EM, Miecznikowski JC, Perez P, Twohig J, Warner BM, Romano RA, Kramer JM.   +9 more
europepmc   +1 more source

Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis. [PDF]

Crit Care, 2023
Wang H, Wang M, Chen J, Hou H, Guo Z, Yang H, Tang H, Chen B.   +7 more
europepmc   +1 more source