FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis. [PDF]
Allergy Asthma Clin Immunol, 2023 Gu J +7 more
europepmc +1 more source
The Effective Tax Rate and the Pretax Rate of Return [PDF]
This paper presents new estimates of the taxes paid on nonfinancial corporate capital, on the pretax rate of return to capital, and on the effective tax rate.
James M. Poterba +2 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis. [PDF]
Crit Care, 2023 Wang H +7 more
europepmc +1 more source
A preliminary design and analysis of an advanced heat-rejection system for an extreme altitude advanced variable cycle diesel engine installed in a high-altitude advanced research platform [PDF]
Satellite surveillance in such areas as the Antarctic indicates that from time to time concentration of ozone grows and shrinks. An effort to obtain useful atmospheric data for determining the causes of ozone depletion would require a flight capable of ...
Johnston, Richard P.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD. [PDF]
JCI Insight, 2022 Baker JR +9 more
europepmc +1 more source
Analysis of tectonic features in US southwest from Skylab photographs [PDF]
The author has identified the following significant results. Skylab photographs were utilized to study faults and tectonic lines in selected areas of the U.S. Southwest.
Abdel-Gawad, M., Tubbesing, L.
core +1 more source