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The role of IL-36 subfamily in intestinal disease
Biochemical Society Transactions, 2022Interleukin (IL)-36 is a subfamily, of the IL-1 super-family and includes IL-36α, IL-36β, IL-36γ, IL-38 and IL-36Ra. IL-36 cytokines are involved in the pathology of multiple tissues, including skin, lung, oral cavity, intestine, kidneys and joints. Recent studies suggest that IL-36 signaling regulates autoimmune disease in addition to antibacterial ...
Peng Xu +3 more
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Current Opinion in Pharmacology, 2012
Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human ...
J E, Towne, J E, Sims
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Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human ...
J E, Towne, J E, Sims
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IL-36 family cytokines in protective versus destructive inflammation
Cellular Signalling, 2020The IL-1 family of cytokines and receptors are critical regulators of inflammation. Within the IL-1 family and in contrast to its IL-1 and IL-18 subfamilies, the IL-36 subfamily is still poorly characterized. Three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, one IL-36 receptor (IL-1R6) antagonist, IL-36RA, and one putative IL-1R6 antagonist, IL ...
Yingying Han +5 more
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IL-36 in chronic inflammation and cancer
Cytokine & Growth Factor Reviews, 2020IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP kinases and NF-kappaB. Three subforms of IL-36, denoted IL-36alpha, IL-36beta and IL-36gamma, have been described that require N-terminal cleavage for activation ...
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IL-36 cytokines regulate antiviral immunity
The Journal of Immunology, 2016Abstract Viruses may succeed as pathogens by deploying immune evasion mechanisms aimed at limiting detection by the host. If the host has developed counter strategies to ensure viral clearance is less clear. HSV-1 blocks inflammatory signaling from infected cells by preventing extracellular release of IL-1β.
Liselotte E Jensen, Katelynn A Milora
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Biology of IL-36 cytokines and their role in disease
Seminars in Immunology, 2013IL-36α, IL-36β, IL-36γ, and IL-36Ra, collectively called IL-36 cytokines, are part of the IL-1 family. IL-36α, IL-36β, and IL-36γ are IL-36 receptor (IL-36R) agonists, while IL-36Ra is a receptor antagonist that blocks the activation of IL-36R signaling.
Gresnigt, M.S., Veerdonk, F.L. van de
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IL-36 cytokines are increased in acne and hidradenitis suppurativa
Archives of Dermatological Research, 2017Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in many inflammatory skin diseases ...
DI CAPRIO, ROBERTA +6 more
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IL-36: An Epithelial Cytokine Important in Psoriasis
2013Interleukin-36 (IL-36) refers to three cytokines that are members of the IL-1 family. These cytokines are expressed predominantly but not exclusively by epithelial tissues. Similar to other IL-1 family cytokines, they promote inflammatory responses by activating kinases such as JNK, p38, and the IKKs, and activating transcription factors such as NFκB ...
John E. Sims +3 more
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IL-36: a therapeutic target for ulcerative colitis?
Expert Opinion on Therapeutic Targets, 2022Yasmina E. Hernandez Santana +2 more
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