Results 241 to 250 of about 1,206,376 (271)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

American Transportation in Prosperity and Depression [PDF]

Thor Hultgren
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Measuring Business Cycles [PDF]

Arthur F. Burns, Wesley C. Mitchell
core  

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Lowered IL‐37 gene expression and elevated IL‐37‐producing tissue‐resident immune cells in psoriasis lesional biopsies

Pathology International, 2023
AbstractPsoriasis is an immune cell‐dependent chronic autoimmune skin disorder. Interleukin 37 (IL‐37) is a cytokine belonging to the IL‐1 family that shows anti‐inflammatory and protective effects in various mouse models of psoriasis. Even though various animal models are used to investigate the pathogenic mechanisms of psoriasis, human clinical ...
Aini Wulamujiang, Seyma Ozkanli, Ender Coskunpinar, Halime Tuba Canbaz, Gamze Yesilay, Muhammetnur Tekayev, Kubra Sevgin   +6 more
openaire   +2 more sources

The role of IL-37 in cancer

Medical Oncology, 2016
Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-
Vivi A, Ding, Ziwen, Zhu, Huaping, Xiao, Mark R, Wakefield, Qian, Bai, Yujiang, Fang   +5 more
openaire   +2 more sources

Role of IL-37 in Cardiovascular Disease Inflammation

Canadian Journal of Cardiology, 2019
Inflammation is closely related to the pathogenesis and prognosis of cardiovascular disease (CVD). Interleukin-37 (IL-37), an anti-inflammatory IL-1 family cytokine, shifts cytokine expression from pro- to anti-inflammation via regulation of macrophage polarization and lipid metabolism.
Ziyi Yang, Lin Kang, Yan Wang, Jiaqing Xiang, Qianying Wu, Cong Xu, Yanqing Zhou, Shaoyuan Chen, Hongcheng Fang, Jie Liu, Ming Dong   +10 more
openaire   +2 more sources

IL-37 and 38 signalling in gestational diabetes

Journal of Reproductive Immunology, 2017
Gestational diabetes mellitus (GDM) is still a clinical challenge around world. Inflammation contributes to the pathogenesis of GDM, the precise underlying mechanism remains to be explored. IL-37 and 38 play important role in autoimmunity, but their role in the development of GDM is unclear.
Zhiyan, Yu, Jun, Liu, Rui, Zhang, Xinmei, Huang, Tiange, Sun, Yueyue, Wu, Brett D, Hambly, Shisan, Bao   +7 more
openaire   +2 more sources

Effect of IL-37 on Allergic Airway Inflammation

Annals of the American Thoracic Society, 2016
The new cytokine IL-37 has been described as a negative regulator of innate immunity. It reduces activation of dendritic cells and the production of proinflammatory mediators in murine and human immune cells. Although recent results from the CLARA childhood asthma cohort suggested an impact of IL-37 on human asthma pathogenesis, the receptor for IL-37 ...
Lars, Lunding, Sina, Webering, Christina, Vock, Alexandra, Schröder, Diana, Raedler, Bianca, Schaub, Heinz, Fehrenbach, Michael, Wegmann   +7 more
openaire   +2 more sources