Results 251 to 260 of about 5,184,526 (265)

Insights into IL-37, the role in autoimmune diseases

Autoimmunity Reviews, 2015
Autoimmune diseases are characterized by the impaired function and the destruction of tissues that are caused by an immune response in which aberrant antibodies are generated and attack the body's own cells and tissues. Interleukin (IL) -37, a new member of the IL-1 family, broadly reduces innate inflammation as well as acquired immune responses ...
Wang-Dong, Xu, Yi, Zhao, Yi, Liu
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IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

Current Drug Targets, 2020
Interleukin-37 (IL-37) was discovered as a new member of pro-inflammatory IL-1 superfamily. However, further studies suggested that IL-37 plays a critical anti-inflammatory role in innate and adaptive immunity. IL-37 may suppress the inflammatory process via intracellular SMAD family member 3 (SMAD3) and extracellular IL-18 Receptor alpha (IL-18Rα ...
Junhui, Bai, Yukun, Li, Meixiang, Li, Sijie, Tan, Daichao, Wu   +4 more
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Role of IL-37 in Cardiovascular Disease Inflammation

Canadian Journal of Cardiology, 2019
Inflammation is closely related to the pathogenesis and prognosis of cardiovascular disease (CVD). Interleukin-37 (IL-37), an anti-inflammatory IL-1 family cytokine, shifts cytokine expression from pro- to anti-inflammation via regulation of macrophage polarization and lipid metabolism.
Ziyi Yang, Lin Kang, Yan Wang, Jiaqing Xiang, Qianying Wu, Cong Xu, Yanqing Zhou, Shaoyuan Chen, Hongcheng Fang, Jie Liu, Ming Dong   +10 more
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IL-37 and 38 signalling in gestational diabetes

Journal of Reproductive Immunology, 2017
Gestational diabetes mellitus (GDM) is still a clinical challenge around world. Inflammation contributes to the pathogenesis of GDM, the precise underlying mechanism remains to be explored. IL-37 and 38 play important role in autoimmunity, but their role in the development of GDM is unclear.
Zhiyan, Yu, Jun, Liu, Rui, Zhang, Xinmei, Huang, Tiange, Sun, Yueyue, Wu, Brett D, Hambly, Shisan, Bao   +7 more
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Effect of IL-37 on Allergic Airway Inflammation

Annals of the American Thoracic Society, 2016
Abstract Rationale The new cytokine IL-37 has been described as a negative regulator of innate immunity. It reduces activation of dendritic cells and the production of proinflammatory mediators in murine and human immune cells.
Lars, Lunding, Sina, Webering, Christina, Vock, Alexandra, Schröder, Diana, Raedler, Bianca, Schaub, Heinz, Fehrenbach, Michael, Wegmann   +7 more
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The indirect antiangiogenic effect of IL-37 in the tumor microenvironment

Journal of Leukocyte Biology, 2020
Abstract IL-37, a newly identified IL-1 family cytokine, has been shown to play an important role in inflammatory diseases, autoimmune diseases, and carcinogenesis. IL-37 has been suggested to suppress tumoral angiogenesis, whereas some publications showed that IL-37 promoted angiogenesis through TGF-β signaling in both physiologic and ...
Yu Mei, Ying Zhu, Huey Yee Teo, Yonghao Liu, Yuan Song, Hwee Ying Lim, Zuhairah Binte Hanafi, Veronique Angeli, Haiyan Liu   +8 more
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Increased IL-37 concentrations in patients with arterial calcification

Clinica Chimica Acta, 2016
Our previous study indicates that IL-37 plays a critical role in both atherosclerosis and arterial calcification. However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated.Anterior tibial arterial wall specimens were obtained from 8 patients with type 2 diabetes mellitus and 8 ...
Kunwu Yu, Xiaohong Min, Yingzhong Lin, Ying Huang, Song Huang, Ling Liu, Yudong Peng, Kai Meng, Dazhu Li, Qingwei Ji, Qiutang Zeng   +10 more
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[The expression of human IL-37 in E.coli and preparation and characterization of mouse anti-IL-37 antibody].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014
To construct a prokaryotic expression system for interleukin-37 (IL-37) and prepare its polyclonal antibody.The gene encoding mature interleukin-37 (IL-37m) was amplified by PCR and subcloned into prokaryotic expression vector pET28a. Then the recombinant plasmid pET28a/IL-37m was transformed into E.coli Rosetta and expressed under IPTG induction.
Fuqian, Zhao, Suhui, He, Lingge, He, Miaofen, Lin, Sen, Wang, Zhangquan, Chen   +5 more
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IL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway

Ocular Immunology and Inflammation
This study aims to investigate the role of Interleukin-37 (IL-37) in mouse models of dry eye.Two murine models of dry eye were employed in this investigation.   The evaluation of the anti-inflammatory impact of IL-37 (200 μl, 10 μg/ml) on dry eye mice involved intraperitoneal injections administered once daily for 7 days.
Xiaoxuan, Qi, Yachun, Yang, Danyu, Xiong, Buyun, Lin, Sainan, Wu, Meihuan, Chen, Zhengxuan, Jiang, Qing, Zhang   +7 more
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IL-37: A new player in immune tolerance

Cytokine, 2015
Hui-min, Chen, Mayumi, Fujita
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