Results 241 to 250 of about 5,184,526 (265)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage. [PDF]

Cell Mol Immunol
Cho SX, Rudloff I, Ellisdon AM, Nold-Petry CA, Nold MF.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

DS_10.1177_0022034519847443 – Supplemental material for IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis

, 2019
Supplemental material, DS_10.1177_0022034519847443 for IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis by L. Jing, S. Kim, L. Sun, L. Wang, E. Mildner, K. Divaris, Y. Jiao and S.
L. Jing, S. Kim, L. Sun, L. Wang, E. Mildner, K. Divaris, Y. Jiao, S. Offenbacher   +7 more
openaire   +2 more sources

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The potential role of IL-37 in atherosclerosis

Die Pharmazie, 2013
Atherosclerosis is an inflammatory disease characterized by extensive lipid deposition and atherosclerotic plaque formation in the intima. Interleukin (IL)-37 is anti-inflammatory cytokine in the IL-1 ligand family. Given that IL-37 plays an important function in the development and progression of inflammatory and autoimmune diseases, it may be ...
Bang-Wei, Wu, Qiu-Tang, Zeng, Kai, Meng, Qing-Wei, Ji   +3 more
openaire   +3 more sources

The role of IL-37 in cancer

Medical Oncology, 2016
Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-
Vivi A, Ding, Ziwen, Zhu, Huaping, Xiao, Mark R, Wakefield, Qian, Bai, Yujiang, Fang   +5 more
openaire   +2 more sources

Dual role of IL-37 in the progression of tumors

Cytokine, 2022
Interleukin (IL)-37 is a novel defined cytokine that belongs to IL-1 family, which possesses potent anti-inflammatory and immunosuppressive properties. The IL-37 protein mainly exists in the cytoplasm of monocytes and is also expressed in epithelial cells and T cells. IL-37 is produced as a precursor which works in mature or immature isoforms without a
Yanglin, Zhu, Hong, Qin, Kui, Ye, Chenglu, Sun, Yafei, Qin, Guangming, Li, Hongda, Wang, Hao, Wang   +7 more
openaire   +2 more sources

Mesenchymal stem cells and IL-37: a powerful combination.

Journal of biological regulators and homeostatic agents, 2019
Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family.
Gugliandolo, A, Caraffa, A L, Gallenga, C E, Kritas, S K, Ronconi, G, Trubiani, O, Conti, P, Di Emidio, P, Mazzon, E   +8 more
openaire   +3 more sources