Results 241 to 250 of about 1,233,492 (271)
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Anti-Inflammatory Effect of Atorvastatin and Rosuvastatin on Monosodium Urate-Induced Inflammation through IL-37/Smad3-Complex Activation in an In Vitro Study Using THP-1 Macrophages. [PDF]
Pharmaceuticals (Basel)Kim SK, Choe JY, Kim JW, Park KY, Kim B.
europepmc +1 more source
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Pathology International, 2023
AbstractPsoriasis is an immune cell‐dependent chronic autoimmune skin disorder. Interleukin 37 (IL‐37) is a cytokine belonging to the IL‐1 family that shows anti‐inflammatory and protective effects in various mouse models of psoriasis. Even though various animal models are used to investigate the pathogenic mechanisms of psoriasis, human clinical ...
Aini Wulamujiang +6 more
openaire +2 more sources
AbstractPsoriasis is an immune cell‐dependent chronic autoimmune skin disorder. Interleukin 37 (IL‐37) is a cytokine belonging to the IL‐1 family that shows anti‐inflammatory and protective effects in various mouse models of psoriasis. Even though various animal models are used to investigate the pathogenic mechanisms of psoriasis, human clinical ...
Aini Wulamujiang +6 more
openaire +2 more sources
Medical Oncology, 2016
Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-
Vivi A, Ding +5 more
openaire +2 more sources
Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-
Vivi A, Ding +5 more
openaire +2 more sources
Role of IL-37 in Cardiovascular Disease Inflammation
Canadian Journal of Cardiology, 2019Inflammation is closely related to the pathogenesis and prognosis of cardiovascular disease (CVD). Interleukin-37 (IL-37), an anti-inflammatory IL-1 family cytokine, shifts cytokine expression from pro- to anti-inflammation via regulation of macrophage polarization and lipid metabolism.
Ziyi Yang +10 more
openaire +2 more sources
IL-37 and 38 signalling in gestational diabetes
Journal of Reproductive Immunology, 2017Gestational diabetes mellitus (GDM) is still a clinical challenge around world. Inflammation contributes to the pathogenesis of GDM, the precise underlying mechanism remains to be explored. IL-37 and 38 play important role in autoimmunity, but their role in the development of GDM is unclear.
Zhiyan, Yu +7 more
openaire +2 more sources
Effect of IL-37 on Allergic Airway Inflammation
Annals of the American Thoracic Society, 2016The new cytokine IL-37 has been described as a negative regulator of innate immunity. It reduces activation of dendritic cells and the production of proinflammatory mediators in murine and human immune cells. Although recent results from the CLARA childhood asthma cohort suggested an impact of IL-37 on human asthma pathogenesis, the receptor for IL-37 ...
Lars, Lunding +7 more
openaire +2 more sources