Results 251 to 260 of about 1,206,376 (271)

Association between IL-37 and Systemic Lupus Erythematosus Risk

Immunological Investigations, 2021
Interleukin-37 (IL-37) is an anti-inflammatory cytokine. In our former study, we found increased plasma IL-37 levels in systemic lupus erythematosus (SLE) patients. However, relationship between IL-37 levels and clinical laboratory characteristics of SLE patients has not been elucidated.
Qian, Wu, Jie, Zhou, Zhi-Chao, Yuan, You-Yu, Lan, Wang-Dong, Xu, An-Fang, Huang   +5 more
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Correlation between serum IL 37 levels with keloid severity

Journal of Cosmetic Dermatology, 2020
AbstractBackgroundKeloids are dermal fibroproliferative disorders that characterized by over deposition of components of the extracellular matrix. Interleukin 37 (IL‐37) is known by its ability to inhibit the proliferation of keloid fibroblasts by inhibiting extracellular matrix production induced by transforming growth factor β (TGF‐β). Thus, Il‐37 is
Fathia M. Khattab, Mai A. Samir
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IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

Current Drug Targets, 2020
Interleukin-37 (IL-37) was discovered as a new member of pro-inflammatory IL-1 superfamily. However, further studies suggested that IL-37 plays a critical anti-inflammatory role in innate and adaptive immunity. IL-37 may suppress the inflammatory process via intracellular SMAD family member 3 (SMAD3) and extracellular IL-18 Receptor alpha (IL-18Rα ...
Junhui, Bai, Yukun, Li, Meixiang, Li, Sijie, Tan, Daichao, Wu   +4 more
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Insights into IL-37, the role in autoimmune diseases

Autoimmunity Reviews, 2015
Autoimmune diseases are characterized by the impaired function and the destruction of tissues that are caused by an immune response in which aberrant antibodies are generated and attack the body's own cells and tissues. Interleukin (IL) -37, a new member of the IL-1 family, broadly reduces innate inflammation as well as acquired immune responses ...
Wang-Dong, Xu, Yi, Zhao, Yi, Liu
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Increased IL-37 concentrations in patients with arterial calcification

Clinica Chimica Acta, 2016
Our previous study indicates that IL-37 plays a critical role in both atherosclerosis and arterial calcification. However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated.Anterior tibial arterial wall specimens were obtained from 8 patients with type 2 diabetes mellitus and 8 ...
Kunwu Yu, Xiaohong Min, Yingzhong Lin, Ying Huang, Song Huang, Ling Liu, Yudong Peng, Kai Meng, Dazhu Li, Qingwei Ji, Qiutang Zeng   +10 more
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DS_10.1177_0022034519847443 – Supplemental material for IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis

2019
Supplemental material, DS_10.1177_0022034519847443 for IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis by L. Jing, S. Kim, L. Sun, L. Wang, E. Mildner, K. Divaris, Y. Jiao and S.
L. Jing, S. Kim, L. Sun, L. Wang, E. Mildner, K. Divaris, Y. Jiao, S. Offenbacher   +7 more
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IL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway

Ocular Immunology and Inflammation
This study aims to investigate the role of Interleukin-37 (IL-37) in mouse models of dry eye.Two murine models of dry eye were employed in this investigation.   The evaluation of the anti-inflammatory impact of IL-37 (200 μl, 10 μg/ml) on dry eye mice involved intraperitoneal injections administered once daily for 7 days.
Xiaoxuan, Qi, Yachun, Yang, Danyu, Xiong, Buyun, Lin, Sainan, Wu, Meihuan, Chen, Zhengxuan, Jiang, Qing, Zhang   +7 more
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Immunomodulatory role of IL-37 in asthma pathogenesis

Pneumologie, 2016
Introduction: Impaired production of interleukin (IL) 37 in allergic asthmatics suggests a role for IL-37 in asthma pathogenesis. We have previously shown that IL-37 ameliorates experimental asthma via a mechanism that requires IL-18 recector (R) α and single Ig IL-1-related receptor (SIGIRR). Aims and objectives: We aim to further clarify, how the
A Schröder, L Lunding, S Webering, C Vock, D Raedler, B Schaub, H Fehrenbach, M Wegmann   +7 more
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Mast Cells Mediate Rheumatoid Arthritis-Inhibitory Role of IL-37

Critical Reviews in Immunology, 2019
Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory, disabling arthropathy that severely affects the quality of life. This disease involves several proinflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor (TNF). IL-1 induces TNF and vice versa, causing joint damage and cartilage degradation.
Conti P., Lauritano D., Caraffa A., Gallenga C. E., Carinci F., Ronconi G., Kritas S. K., Di Emidio P., Martinotti S., Pandolfi F.   +9 more
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[The expression of human IL-37 in E.coli and preparation and characterization of mouse anti-IL-37 antibody].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014
To construct a prokaryotic expression system for interleukin-37 (IL-37) and prepare its polyclonal antibody.The gene encoding mature interleukin-37 (IL-37m) was amplified by PCR and subcloned into prokaryotic expression vector pET28a. Then the recombinant plasmid pET28a/IL-37m was transformed into E.coli Rosetta and expressed under IPTG induction.
Fuqian, Zhao, Suhui, He, Lingge, He, Miaofen, Lin, Sen, Wang, Zhangquan, Chen   +5 more
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