IL-38 Gene Deletion Worsens Murine Colitis [PDF]
Frontiers in Immunology, 2022 IL-38 is a recently discovered cytokine and member of the IL-1 Family. In the IL-1 Family, IL-38 is unique because the cytokine is primarily a B lymphocyte product and functions to suppress inflammation. Studies in humans with inflammatory bowel disease (
Dennis M. de Graaf +13 more
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The Role of IL-37 and IL-38 in Colorectal Cancer [PDF]
Frontiers in Medicine, 2022 Colorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases.
Jie Dang +8 more
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The Role of IL-37 and IL-38 in Obstetrics Abnormalities [PDF]
Frontiers in Medicine, 2021 There are two fairly common complications during pregnancy, i.e., gestational diabetes mellitus (GDM) and pre-eclampsia, which are independent, but are also closely linked in prevalence in pregnant women, with potential serious adverse consequences.
Mei Wang
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Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]
Frontiers in ImmunologyMembers of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
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Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients [PDF]
International Journal of General Medicine, 2023 Chengbo Lu,1,* Fanghui Zhou,2,* Huimin Xian,3,* Siyuan Sun,4 Jingkun Yue,4 Ying Zhang,5 Qi Zhao,6 Xing Luo,3 Yang Li7 1Department of Cardiology, 1st Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, People’s Republic of China;
Lu C +8 more
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IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation [PDF]
mAbs, 2023 Immune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients.
John P. Dowling +14 more
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The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications [PDF]
Frontiers in ImmunologyLung cancer, a significant global health challenge, is primarily classified into non-small cell lung cancer (NSCLC) and small cell lung cancer. Despite advancements in targeted therapies and immunotherapies, NSCLC outcomes remain poor, with low five-year
Jiwei Zhang +4 more
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The role of IL-37 and IL-38 in rheumatoid arthritis, the potential clinical applications in precision medicine [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder that primarily affects the joints, and in severe cases, can damage other major organs, particularly in susceptible individuals.
Haifeng Zhang +6 more
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The differential role of IL-33 and IL-38 in prostate cancer, contradictory roles [PDF]
Frontiers in ImmunologyProstate cancer (PCa) is still as a major cause of morbidity and mortality in men at the global level, highlighting the necessity for improved diagnostic and therapeutic strategies beyond current PSA screening limitations. This mini-review focuses on the
Runfen Ban +3 more
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Butyrophilin 3A1 Contributes to Inflammation and Induces a Lupus‐Like Disease by Inhibiting the IL‐38‐Ferroptosis Axis [PDF]
MedCommSystemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin. Recent evidence has linked butyrophilin 3A1 (BTN3A1) to immune dysregulation. This study was to elucidate the relationship of BTN3A1 in SLE. Expression of BTN3A1 in plasma and
Wang‐Dong Xu +9 more
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