IL-38 promotes the development of prostate cancer [PDF]
Frontiers in ImmunologyIntroductionProstate Cancer (PCa) remains a significant concern in male cancer-related mortality. Tumour development is intricately regulated by the complex interactions between tumour cells and their microenvironment, making it essential to determine ...
Huiyan Wu +9 more
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IL‐38 attenuates myocardial ischemia–reperfusion injury by inhibiting macrophage inflammation [PDF]
Immunity, Inflammation and Disease, 2023 Background Reperfusion therapy is the most effective approach to resolve coronary occlusion, but myocardial injury caused by excessive inflammation during myocardial ischemia–reperfusion will also pose a new threat to health. Our prior study revealed the
Yuzhen Wei +6 more
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The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases [PDF]
Frontiers in Pharmacology, 2021 Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a
Miao-miao Han +12 more
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IL-38: A New Player in Inflammatory Autoimmune Disorders [PDF]
Biomolecules, 2019 Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36
Lihui Xie +5 more
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IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells [PDF]
Cell Reports, 2019 Summary: Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients.
Yingying Han +19 more
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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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The role of IL-38 in intestinal diseases - its potential as a therapeutic target [PDF]
Frontiers in Immunology, 2022 IL-38, an anti-inflammatory cytokine, is a key regulator of homeostasis in host immunity. Intestinal immunity plays a critical role in defence against pathogenic invasion, as it is the largest surface organ and the most common entry point for micro ...
Qiang Wang +4 more
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Role of IL-38 and Its Related Cytokines in Inflammation [PDF]
Mediators of Inflammation, 2015 Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor
Xianli Yuan +3 more
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IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome [PDF]
Mediators of Inflammation, 2021 Interleukin- (IL-) 38 is an emerging cytokine with multiple functions involved in infection and immunity. However, the potential role of IL-38 in the host immune response during sepsis remains elusive.
Yun Ge +4 more
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors [PDF]
Cell Communication and SignalingBackground Interleukin (IL)-38 is an IL-1 family cytokine that was proposed to exert anti-inflammatory effects. However, its mechanisms of action are not well understood and the identity of the IL-38 receptor(s) remains debated.
Alejandro Diaz-Barreiro +8 more
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