Results 21 to 30 of about 961,718 (249)

IL-38 attenuates vascular calcification by upregulating GPX3-mediated antioxidant defense via the PPAR-γ/NRF2 axis [PDF]

Cellular and Molecular Life Sciences
Vascular calcification is a pathological process commonly associated with cardiovascular diseases, diabetes, and renal insufficiency, driven by inflammation, oxidative stress, and endoplasmic reticulum stress. IL-38, a member of the IL-1 cytokine family,
Lei Zhu, Qiang Wang, Bingliang Shang, Jun Cui, Yujie Song, Bing Zhang, Wenlong Chen, Jialin Xin, Yang Cui, Rui Liu, Panpan Li, Lanrui Jing, Haitao Zhou, Wangxia Tang, Yang Sun, Wei Yi   +15 more
doaj   +2 more sources

Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis [PDF]

Iranian Journal of Immunology, 2023
Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)-38 is thought to be involved in inhibiting cytokine secretion in the Th17 pathway.Objective: To evaluate the regulatory function of
Xiaoqiang Wang, Yang Shen, Xia Ke, Suling Hong   +3 more
doaj   +3 more sources

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes [PDF]

Frontiers in Immunology
IntroductionColorectal cancer (CRC) presents a substantial challenge characterized by unacceptably high mortality and morbidity, primarily attributed to delayed diagnosis and reliance on palliative care.
Liuhong Yuan, Zhenyu Tan, Junjie Huang, Feier Chen, Brett D. Hambly, Shisan Bao, Kun Tao   +6 more
doaj   +2 more sources

IL-38 orchestrates proliferation and differentiation in human keratinocytes. [PDF]

Exp Dermatol, 2022
AbstractInterleukin (IL)‐38 is a member of the IL‐1 cytokine family with reported anti‐inflammatory activity. The highest constitutive IL‐38 expression is detected in the skin, where it is mainly produced by differentiating keratinocytes. However, little data are available regarding its biological functions.
Mermoud L, Shutova M, Diaz-Barreiro A, Talabot-Ayer D, Drukala J, Wolnicki M, Kaya G, Boehncke WH, Palmer G, Borowczyk J.   +9 more
europepmc   +4 more sources

The emerging role of IL-38 in diseases: A comprehensive review. [PDF]

Immun Inflamm Dis, 2023
AbstractIntroductionInterleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases.AimThis review aims to detail the biological function,
Chen W, Xi S, Ke Y, Lei Y.
europepmc   +4 more sources

Effects of IL-38 on Macrophages and Myocardial Ischemic Injury. [PDF]

Front Immunol, 2022
Macrophages play an important role in clearing necrotic myocardial tissues, myocardial ischemia–reperfusion injury, and ventricular remodeling after myocardial infarction. M1 macrophages not only participate in the inflammatory response in myocardial tissues after infarction, which causes heart damage, but also exert a protective effect on the heart ...
Li Z, Ding Y, Peng Y, Yu J, Pan C, Cai Y, Dong Q, Zhong Y, Zhu R, Yu K, Zeng Q.   +10 more
europepmc   +4 more sources

Oxidation-sensitive cysteines drive IL-38 amyloid formation

, 2023
AbstractCytokines of the interleukin (IL)-1 family are widely expressed in epithelial surfaces, including the epidermis, where they play a key role in the maintenance of barrier integrity and host defense. A recent report associated the IL-1 family member IL-33 with stress granules (SGs) in epithelial cells.
Diaz-Barreiro A, Cereghetti G, Tonacini J, Talabot-Ayer D, Kieffer-Jaquinod S, Huard A, Swale C, Couté Y, Peter M, Francés-Monerris A, Palmer G.   +10 more
europepmc   +3 more sources

Multifaceted roles of IL-38 in inflammation and cancer

Cytokine, 2022
Interleukin (IL)-38 is the least well-understood cytokine of the IL-1 family. Since its discovery twenty years ago, numerous studies have linked IL-38 to diverse pathologies, especially in the context of autoimmune and inflammatory processes, while its role in cancer has been less explored.
Diaz Barreiro, Alejandro, Huard, Arnaud, Palmer-Lourenco, Gaby   +2 more
openaire   +4 more sources

Cell Intrinsic IL-38 Affects B Cell Differentiation and Antibody Production. [PDF]

Int J Mol Sci, 2023
IL-38 is an IL-1 family receptor antagonist with an emerging role in chronic inflammatory diseases. IL-38 expression has been mainly observed not only in epithelia, but also in cells of the immune system, including macrophages and B cells. Given the association of both IL-38 and B cells with chronic inflammation, we explored if IL-38 affects B cell ...
Huard A, Wilmes C, Kiprina A, Netzer C, Palmer G, Brüne B, Weigert A.   +6 more
europepmc   +6 more sources

IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis. [PDF]

J Cell Mol Med, 2020
AbstractIL‐38 is a newly identified cytokine that belongs to the IL‐1 family. In our previous study, we found elevated plasma levels of IL‐38 in patients with systemic lupus erythematosus (SLE). However, the clear relationship of IL‐38 expression in plasma, peripheral blood mononuclear cells (PBMCs) and clinical and laboratory features needs ...
Xu WD, Su LC, Liu XY, Wang JM, Yuan ZC, Qin Z, Zhou XP, Huang AF.   +7 more
europepmc   +4 more sources