Results 101 to 110 of about 55,844,280 (246)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
EspacesTemps.net, 2004 C'est d'abord à Marseille, ville dérangée, couleur et bruit. À l'approche d'une rue, il arrive, et ce n'est pas si rare, que le conducteur pile afin de vous laisser passer, fragile piéton. Il fait alors un geste de la main, souvent un
Emmanuelle Tricoire
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Huntington ou la culture de l'ennemi.
EspacesTemps.net, 2003 « Savoir de qui nous devons avoir peur » (p. 66), et accréditer « l'idée qu'il n'y a pas de politique sans désignation de l'ennemi » (p. 75) : tels sont pour Marc Crépon deux des principaux objectifs de Samuel Huntington dans son ouvrage ...
René-Éric Dagorn
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Marco Dotti,Il mercato dell'incertezza
, 2017 il cerdito correlato all'attività di un Luogo Pio nella Brescia d'Antico ...
BORELLI, Giorgio
core +1 more source
Ganesh s'est mis à l'informatique !
EspacesTemps.net, 2004 Ganesh, demi-dieu de l'hindouisme, possède un corps d'homme sur lequel trône une tête d'éléphant. C'est simplement parce qu'enfant, il voulut tenir tête à l'époux de sa mère, Shiva, qui de retour de campagne ne sut le reconnaître.
Blandine Ripert
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
EspacesTemps.net, 2003 Il y a quelques semaines, un membre de la rédaction d'EspacesTemps. net a reçu cette carte, sans commentaire clair et vérifiable quant à sa provenance, au contexte de sa production, et plus généralement quant à ses conditions de production.
Patrick Poncet
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source