Results 111 to 120 of about 55,844,280 (246)

Approcher la Finlande.

open access: yesEspacesTemps.net, 2004
Cet ouvrage est fondé sur Finland, a cultural encyclopedia paru en 1997 ; il s'agit donc bien d'une traduction mais le terme d'encyclopédie a été considéré comme trop connoté dans la culture française depuis Diderot et d'Alembert, aussi ...
Isabelle Debilly
doaj  

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

‘La parole comme instrument de la vérité.’

open access: yesEspacesTemps.net, 2003
La nouvelle vient de tomber, inattendue : Socrate est traduit devant le tribunal ! C'est comme un coup de tonnerre dans l'esprit de Platon, qui décide de réagir en écrivant l'Apologie de Socrate .
Louis-David Delahaye
doaj  

Il contributo economico-aziendale delle coperture finanziarie e le regole di hedge accounting dello IAS 39

open access: yes, 2003
Questo contributo argomenta l'opinione che le regole di hedge accounting proposte nello IAS 39 riflettono ragionevoli esigenze contabili ma non assicurano un utilizzo economico delle coperture finanziarie nelle imprese.
CONTI, CESARE
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Tre Sonate per il Clavicembalo o Forte Piano : Opera 39 / dal Sigr. Muzio Clementi [PDF]

open access: yes
TRE SONATE PER IL CLAVICEMBALO O FORTE PIANO : OPERA 39 / DAL SIGR. MUZIO CLEMENTI Tre Sonate per il Clavicembalo o Forte Piano : Opera 39 / dal Sigr. Muzio Clementi (1) Titelseite (1) Sonata I. (2) Sonata II.
Clementi, Muzio
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Le concept d' histoire dans la philosophie de Gilles-Gaston Granger.

open access: yesEspacesTemps.net, 2004
Granger a développé durant toute sa carrière une réflexion très rigoureuse sur les sciences, dans la lignée de la tradition française du rationalisme appliqué.
Philippe Lacour
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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