Results 181 to 190 of about 15,466,885 (336)

IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV. [PDF]

J Infect Dis
Ofotokun I, Titanji K, Dabeer S, Tripathi AK, Bedi B, Kirkpatrick CM, Nguyen TB, Weitzmann MN.   +7 more
europepmc   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine. [PDF]

NPJ Vaccines
Robinson TM, Bolton JS, Duncan EH, Bergmann-Leitner ES, Mura M.   +4 more
europepmc   +1 more source

A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma

International Archives of Allergy and Immunology, 2016
D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, G. Canonica   +4 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

γδ T cell-derived IL-4 initiates CD8⁺ T cell immunity. [PDF]

Nat Immunol
Le S, Dooley N, Murphy D, Liu S, Gandolfo LC, Ge Z, May R, Cozijnsen A, Burn TN, Jennison C, Bachem A, Xu C, Koay HF, Schröder J, Oyong D, Nalubega M, Kenangalem E, Gras S, Cockburn IA, Bedoui S, Mackay LK, McFadden GI, Fernandez-Ruiz D, Boyle M, Heath WR, Beattie L.   +25 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

IL-4/Nanohydroxyapatite Codelivery in a Dual-Bionic Scaffold: Design and Immunomodulatory Endogenous Osteogenesis Mechanism. [PDF]

ACS Appl Mater Interfaces
Wang FZ, Yu Y, Soh HY, Liu S, Hu LH, Tang ZN, Zhang WB, Peng X.   +7 more
europepmc   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

IL-4 variant and school mouse exposure increases asthma morbidity in urban schoolchildren. [PDF]

J Allergy Clin Immunol
Ruran HB, Jung YS, Chen Q, Nadeau K, Phipatanakul W, Chatila TA.   +5 more
europepmc   +1 more source