Results 191 to 200 of about 2,017,899 (336)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Mechanism of IL-4 mediated RPL19 promoting malignant progression in HER2 positive breast cancer. [PDF]

Breast Cancer Res
Zhang N, Zhang J, Shao J, Huang Z, Zhang J, Wang H, Lv L, Shen Z, Zhang P, Liu B, Zhang G, Shan M.   +11 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine. [PDF]

NPJ Vaccines
Robinson TM, Bolton JS, Duncan EH, Bergmann-Leitner ES, Mura M.   +4 more
europepmc   +1 more source

Natoli S., Libertà e destino nella tragedia greca , coll. Uomini e Profeti 10, Brescia, Morcelliana, 2002, 19x12, 142 p., 12 €. ISBN 88-372-1883-4 ; Id ., Il cristianesimo di un non credente , coll. Sympathetika, Magnano, Qiqajon, 2002, 17x12, 91 p., 6 €. ISBN 88-8227-125-0 [PDF]

, 2005

openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

γδ T cell-derived IL-4 initiates CD8⁺ T cell immunity. [PDF]

Nat Immunol
Le S, Dooley N, Murphy D, Liu S, Gandolfo LC, Ge Z, May R, Cozijnsen A, Burn TN, Jennison C, Bachem A, Xu C, Koay HF, Schröder J, Oyong D, Nalubega M, Kenangalem E, Gras S, Cockburn IA, Bedoui S, Mackay LK, McFadden GI, Fernandez-Ruiz D, Boyle M, Heath WR, Beattie L.   +25 more
europepmc   +1 more source

The expansion in lymphoid organs of IL-4 ⁺ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo [PDF]

, 2018
Takashi Maehara, Hamid Mattoo, Vinay S. Mahajan, Samuel J. H. Murphy, Grace J. Yuen, Noriko Ishiguro, Miho Ohta, Masafumi Moriyama, Takako Saeki, Hidetaka Yamamoto, Masaki Yamauchi, Joe Daccache, Tamotsu Kiyoshima, Seiji Nakamura, John H. Stone, Shiv Pillai   +15 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Pulmonary surfactant protein D reduces lung cancer progression associated with decreased IL-4/STAT6 signaling. [PDF]

NPJ Precis Oncol
Mohammadi A, Inayatullah M, Schlosser A, Pilecki B, Marcussen N, Ünsal S, Mansoori B, Baradaran B, Tallouzi Y, Gjerstorff MF, Graversen J, Ravnskjær K, Tiwari VK, Terp MG, Sorensen GL.   +14 more
europepmc   +1 more source