Results 181 to 190 of about 96,694,076 (289)

Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13. [PDF]

Pediatr Allergy Immunol
Metwally NKA, Hashimoto S, Vijverberg SJH, Neerincx AH, Dierdorp BS, Dekker T, Haarman EG, Duitman JW, Gorenjak M, Toncheva AA, Harner S, Brandstetter S, Wolff C, Corcuera-Elosegui P, López-Fernández L, Sardón-Prado O, Pino-Yanes M, Potočnik U, Kabesch M, Kraneveld AD, Lutter R, Terheggen-Lagro SWJ, Abdel-Aziz MI, Maitland-van der Zee AH, SysPharmPediA Consortium.   +24 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Il settore Lattanzi della necropoli di Norchia ed il contesto della tomba 3

Il capitolo presenta il contesto e lo scavo della tomba della necropoli dei Lattanzi a Norchia, in cui nel 2024 è stato rinvenuto uno stamnos decorato e ...
Daniel Morleghem
core  

Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis. [PDF]

Nucleic Acids Res
Varga Z, Poscher A, Váradi EA, Cinege G, Izsán A, Erdős E, Benyhe-Kis B, Tihanyi AZ, Tzerpos P, Bene K, Halász L, Gémes N, Neuperger P, Tóth M, Migh E, Póliska S, Szebeni GJ, Walter JE, Dániel B, Csörgő B, Nagy L, Czimmerer Z.   +21 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response. [PDF]

Sci Adv
Blanco-Fernandez J, Lisci M, Foged MM, Chapuis C, Pflästerer T, Kleele T, Jourdain AA.   +6 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Elevated IL-4 and IL-13 Expression in Hailey-Hailey Disease: Evidence for Th2-Mediated Pathogenesis and Targeted Treatment. [PDF]

J Cutan Pathol
Gaumond SI, Soto V, Abujamra BA, Rongioletti F, McGrath JA, Jozic I, Romanelli P.   +6 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

IL-4 triggers salivary duct dilatation via SHH signaling and exacerbates Sjögren's disease. [PDF]

Cell Rep
Zhang J, Zhang J, Zhao Y, Yang X, Li J, Chen W, Wang X, Shi X, Chang X, Sun Q, Chen W, Wang F.   +11 more
europepmc   +1 more source