Results 291 to 300 of about 15,466,885 (336)
Some of the next articles are maybe not open access.
The Journal of Immunology, 1996
Abstract Alternative splicing of mRNA can generate protein isoforms that are preferentially expressed in different tissues or during different states of cell differentiation or activation. Protein isoforms may have different functions.
S P, Atamas +3 more
openaire +2 more sources
Abstract Alternative splicing of mRNA can generate protein isoforms that are preferentially expressed in different tissues or during different states of cell differentiation or activation. Protein isoforms may have different functions.
S P, Atamas +3 more
openaire +2 more sources
Aspirin inhibits IL-4 production
Trends in Immunology, 2001The anti-inflammatory properties of aspirin are well-recognized and have been chiefly attributed to the effect of aspirin on prostaglandins. It is known that aspirin inhibits cyclo-oxygenase, the enzyme which catalyzes the production of prostaglandin from cell-membrane fatty-acid precursors.
openaire +2 more sources
2021
The distribution of SNP C-589 (rs2243250) of the promoter region of the regulatory cytokine IL-4 gene was analyzed with the help of the pilot research among patients of the pulmonary department of the Adygeya Republican Clinical Hospital who had given their informed consent (n = 11, average age 45). They had severe mixed forms of bronchial asthma (BA)
openaire +1 more source
The distribution of SNP C-589 (rs2243250) of the promoter region of the regulatory cytokine IL-4 gene was analyzed with the help of the pilot research among patients of the pulmonary department of the Adygeya Republican Clinical Hospital who had given their informed consent (n = 11, average age 45). They had severe mixed forms of bronchial asthma (BA)
openaire +1 more source
Probabilistic Regulation of IL-4 Production
Journal of Clinical Immunology, 2005Among a population of uniformly differentiated TH(2) cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene.
Liying, Guo +2 more
openaire +2 more sources
Transplantation, 1997
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclonal 11B11, 1D11, and 24G2 anti-IL-4 antibodies were used to detect cell-surface and cytoplasmic antigens ...
P L, Mottram +4 more
openaire +1 more source
We analyzed cytokine expression in recipient spleens and cardiac allografts placed in mice that were unable to synthesize interleukin (IL)-4 due to disruption of the IL-4 gene (IL-4 -/-) and in wild-type (IL-4 +/+) mice. Polyclonal BL-4P and monoclonal 11B11, 1D11, and 24G2 anti-IL-4 antibodies were used to detect cell-surface and cytoplasmic antigens ...
P L, Mottram +4 more
openaire +1 more source
1995
Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
openaire +1 more source
Abstract The nucleotide sequences of IL-4 cDNAs cloned from mouse and man (GenBank accession numbers M13238 and M13982) predict a protein of 153 (human) or 140 (mouse) amino acids, each containing a 20-amino-acid leader sequence (Lee et al. 1986; Noma et al. 1986; Yokota et al. 1986).
M Howard, N Harada
openaire +1 more source
The IL-4 Receptor — Signaling Mechanisms
1994Interleukin-4 (IL-4) is a multifunctional cytokine that is a member of the hematopoietin family1. Its structure consists of a bundle of four left handed α helices in which the first and second and the third and fourth helices are connected by long over hand loops2,3,4,5.
A, Keegan, K, Nelms, W E, Paul
openaire +2 more sources
Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Helper T cells can be divided into Th1 type cell which produces IL-2 and IFN-gamma and Th2 type cell which produces IL-4, IL-5, and IL-6. In general, cytokine has a pleiotropic action. Furthermore cytokines have redundancy in their action. IL-4 is a major product of Th 2 type cell and is an essential cytokine for IgE production, which is also induced ...
N, Nagai +3 more
openaire +1 more source
Helper T cells can be divided into Th1 type cell which produces IL-2 and IFN-gamma and Th2 type cell which produces IL-4, IL-5, and IL-6. In general, cytokine has a pleiotropic action. Furthermore cytokines have redundancy in their action. IL-4 is a major product of Th 2 type cell and is an essential cytokine for IgE production, which is also induced ...
N, Nagai +3 more
openaire +1 more source
The IL-4 receptor: signaling mechanisms and biologic functions.
Annual Review of Immunology, 1999K. Nelms +4 more
semanticscholar +1 more source